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Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane. Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cytochrome-c oxidase activity
Acc: GO:0004129
Aspect: Molecular Function
Desc: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
Synonyms:
  • cbb3-type cytochrome c oxidase
  • ferrocytochrome-c:oxygen oxidoreductase
  • indophenolase
  • warburg's respiratory enzyme activity
  • caa3-type cytochrome c oxidase
  • ba3-type cytochrome c oxidase
  • ferrocytochrome c oxidase
  • indophenol oxidase
  • cytochrome oxidase activity
  • aa3-type cytochrome c oxidase
  • NADH cytochrome c oxidase
  • complex IV (mitochondrial electron transport) activity
  • cytochrome aa3 activity
  • cytochrome a3 activity
Proteins in PDR annotated with:
   This term: 200 [Search]
   Term or descendants: 200 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004129 - cytochrome-c oxidase activity (interactive image map)
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Created and Maintained by: Michael Riffle