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Protein Overview: COX4

General Information:
Name(s) found: COX4 / YGL187C [SGD]
Description(s) found:
Found 40 descriptions.
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  • Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 155 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial respiratory chain complex IV [IPILink to PubMed article]
    Biological Process: mitochondrial electron transport, cytochrome c to oxygen [IDALink to PubMed article]
    aerobic respiration [IPILink to PubMed article]
    Molecular Function: zinc ion binding [IDALink to PubMed article]
    cytochrome-c oxidase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG AKEGTVPTDL  60
   61 DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII ESYDDYRYVG CTGSPAGSHT 120
  121 IMWLKPTVNE VARCWECGSV YKLNPVGVPN DDHHH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9
    View Details Krogan NJ, et al. (2006) COX4 COX5A
    View Details Gavin AC, et al. (2002) COX4 COX5A COX6
    View Details Qiu et al. (2008) AAC1 ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP2 ATP20 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYC1 CYT1 INH1 MCR1 OLI1 QCR2 QCR6 QCR7 QCR8 RIP1 SDH1 SDH2 SDH3 SDH4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HSL7 COX4 2 Unpublished Fields Lab Data
    View Screen NPA3 COX4 2 Unpublished Fields Lab Data
    View Screen RPN5 COX4 1 Unpublished Fields Lab Data
    View Screen BUR2 COX4 1 Unpublished Fields Lab Data
    View Screen HMT1 COX4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COX4 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 120.156545 Cytochrome c oxidase Subunit F
    2 View Details [77..155] PSI-BLAST 30.69897 No description for 2odxA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle