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Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions. Catalysis of the removal of a serine- or threonine-bound phosphate group from a protein; action dependent on magnesium. Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. null Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein serine/threonine phosphatase activity
Acc: GO:0004722
Aspect: Molecular Function
Desc: Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.
Synonyms:
  • phosphatase 2A
  • phosphatase 2B
  • GO:0015071
  • calcineurin
  • protein phosphatase type 2C activity
  • GO:0000158
  • casein phosphatase
  • GO:0008600
  • phosphatase IB
  • protein phosphatase type 4, intrinsic catalyst activity
  • branched-chain alpha-keto acid dehydrogenase phosphatase
  • GO:0000163
  • phosphatase SP
  • phosphatase C-II
  • phosphatase II
  • protein phosphatase type 2B activity
  • serine/threonine specific protein phosphatase activity
  • protein D phosphatase
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • phosphospectrin phosphatase
  • phosphopyruvate dehydrogenase phosphatase
  • protein phosphatase type 4 activity
  • phosphatase IV
  • protein phosphatase type 2A, intrinsic catalyst activity
  • protein phosphatase type 1 activity
  • GO:0030361
  • GO:0030360
  • GO:0008598
  • Aspergillus awamori acid protein phosphatase
  • protein phosphatase type 2B, intrinsic catalyst activity
  • BCKDH phosphatase
  • HMG-CoA reductase phosphatase
  • phosphatase H-II
  • protein phosphatase type 2A activity
  • polycation modulated (PCM-) phosphatase
  • protein phosphatase X
  • phosphatase III
  • GO:0030358
  • phosphatase I
  • GO:0030357
  • protein phosphatase type 1, intrinsic catalyst activity
Proteins in PDR annotated with:
   This term: 367 [Search]
   Term or descendants: 405 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004722 - protein serine/threonine phosphatase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle