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View Structure Prediction Details

Protein: ATP1
Organism: Saccharomyces cerevisiae
Length: 545 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATP1.

Description E-value Query
Range		 Subject
Range
ATPA_RAT - ATP synthase subunit alpha, mitochondrial OS=Rattus norvegicus GN=Atp5a1 PE=1 SV=2
 0.0 [9..545] [2..541]
gi|45383566, gi|... - gi|45383566|ref|NP_989617.1| ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit ...
 0.0 [4..545] [7..551]
gi|15030240 - gi|15030240|gb|AAH11384.1| ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1,...
 0.0 [4..545] [7..551]
ATPA_MOUSE - ATP synthase subunit alpha, mitochondrial OS=Mus musculus GN=Atp5a1 PE=1 SV=1
 0.0 [4..545] [7..551]
ATPA_BOVIN - ATP synthase subunit alpha, mitochondrial OS=Bos taurus GN=ATP5A1 PE=1 SV=1
 0.0 [4..545] [7..551]
ATPA_BRUMB - ATP synthase subunit alpha OS=Brucella melitensis biotype 2 (strain ATCC 23457) GN=atpA PE=3 SV=1
ATPA_BRUME - ATP synthase subunit alpha OS=Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) G...
ATPA_BRUME - ATP synthase subunit alpha OS=Brucella melitensis GN=atpA PE=3 SV=1
 0.0 [38..545] [1..508]
ATPA_RHILO - ATP synthase subunit alpha OS=Rhizobium loti GN=atpA PE=3 SV=1
ATPA_RHILO - ATP synthase subunit alpha OS=Rhizobium loti (strain MAFF303099) GN=atpA PE=3 SV=1
 0.0 [38..545] [1..508]
ATP1 - Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily ...
 0.0 [1..545] [1..545]

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Predicted Domain #1
Region A:
Residues: [1-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLARTAAIRS LSRTLINSTK AARPAAAALA STRRLASTKA QPTEVSSILE ERIKGVSDEA  60
   61 NLNETGRVLA VGDGIARVFG LNNIQAEELV EFSSGVKGMA LNLEPGQVGI VLFGSDRLVK 120
  121 EGELVKRTGN I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1cowA_
Description: F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism 10.4627263027269 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 9.07129841752891 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 7.35625288284796 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 6.62734320850541 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 4.03326929098701 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism 3.28373827150339 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
cation-transporting ATPase activity 2.31476707827367 bayes_pls_golite062009
binding 2.21604035604783 bayes_pls_golite062009
cell surface binding 2.12695960098007 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
hydrolase activity 1.65763522573119 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.56007674693172 bayes_pls_golite062009
ribonucleotide binding 1.53142082854758 bayes_pls_golite062009
purine nucleotide binding 1.52938239070386 bayes_pls_golite062009
purine ribonucleotide binding 1.52887308780164 bayes_pls_golite062009
nucleotide binding 1.52746968836881 bayes_pls_golite062009
ATP binding 1.23942044024113 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
adenyl ribonucleotide binding 1.21044170258803 bayes_pls_golite062009
adenyl nucleotide binding 1.19481945569892 bayes_pls_golite062009
voltage-gated cation channel activity 1.03415266410463 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
voltage-gated channel activity 0.908137002406423 bayes_pls_golite062009
voltage-gated ion channel activity 0.905276329867465 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
potassium channel activity 0.843657228494419 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
kinase activity 0.641541011250583 bayes_pls_golite062009
cation channel activity 0.601686039699302 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.563503770238611 bayes_pls_golite062009
protein kinase activity 0.529485140575818 bayes_pls_golite062009
nucleic acid binding 0.503971340374059 bayes_pls_golite062009
drug transmembrane transporter activity 0.46842047319323 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.40876498215632 bayes_pls_golite062009
0.3586311431823 bayes_pls_golite062009
helicase activity 0.32448546535964 bayes_pls_golite062009
gated channel activity 0.299411774392227 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.226231702119567 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.175442402308287 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
ion channel activity 0.154779598791225 bayes_pls_golite062009
passive transmembrane transporter activity 0.134817721656507 bayes_pls_golite062009
channel activity 0.134817721656507 bayes_pls_golite062009
substrate-specific channel activity 0.126911677161968 bayes_pls_golite062009
DNA binding 0.111331583742205 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [132-416] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDVPVGPGLL GRVVDALGNP IDGKGPIDAA GRSRAQVKAP GILPRRSVHE PVQTGLKAVD  60
   61 ALVPIGRGQR ELIIGDRQTG KTAVALDTIL NQKRWNNGSD ESKKLYCVYV AVGQKRSTVA 120
  121 QLVQTLEQHD AMKYSIIVAA TASEAAPLQY LAPFTAASIG EWFRDNGKHA LIVYDDLSKQ 180
  181 AVAYRQLSLL LRRPPGREAY PGDVFYLHPR LLERAAKLSE KEGSGSLTAL PVIETQGGDV 240
  241 SAYIPTNVIS ITDGQIFLEA ELFYKGIRPA INVGLSVSRV GSAAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1cowA_
Description: F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [417-545] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKALKQVAGS LKLFLAQYRE VAAFAQFGSD LDASTKQTLV RGERLTQLLK QNQYSPLATE  60
   61 EQVPLIYAGV NGHLDGIELS RIGEFESSFL SYLKSNHNEL LTEIREKGEL SKELLASLKS 120
  121 ATESFVATF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1cowA_
Description: F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle