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Protein Overview: PUS7

General Information:
Name(s) found: PUS7 / YOR243C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 676 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pseudouridine synthesis [IDALink to PubMed article]
    snRNA modification [IDALink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    tRNA modification [IDALink to PubMed article]
    Molecular Function: pseudouridine synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSSEATVK RPLDAHVGPS ENAAKKLKIE QRTQADGIHE ADVGITLFLS PELPGFRGQI  60
   61 KQRYTDFLVN EIDQEGKVIH LTDKGFKMPK KPQRSKEEVN AEKESEAARR QEFNVDPELR 120
  121 NQLVEIFGEE DVLKIESVYR TANKMETAKN FEDKSVRTKI HQLLREAFKN ELESVTTDTN 180
  181 TFKIARSNRN SRTNKQEKIN QTRDANGVEN WGYGPSKDFI HFTLHKENKD TMEAVNVITK 240
  241 LLRVPSRVIR YAGTKDRRAV TCQRVSISKI GLDRLNALNR TLKGMIIGNY NFSDASLNLG 300
  301 DLKGNEFVVV IRDVTTGNSE VSLEEIVSNG CKSLSENGFI NYFGMQRFGT FSISTHTIGR 360
  361 ELLLSNWKKA AELILSDQDN VLPKSKEARK IWAETKDAAL ALKQMPRQCL AENALLYSLS 420
  421 NQRKEEDGTY SENAYYTAIM KIPRNLRTMY VHAYQSYVWN SIASKRIELH GLKLVVGDLV 480
  481 IDTSEKSPLI SGIDDEDFDE DVREAQFIRA KAVTQEDIDS VKYTMEDVVL PSPGFDVLYP 540
  541 SNEELKQLYV DILKADNMDP FNMRRKVRDF SLAGSYRTVI QKPKSLEYRI IHYDDPSQQL 600
  601 VNTDLDILNN TRAKESGQKY MKAKLDRYMP DKGGEKTAVV LKFQLGTSAY ATMALRELMK 660
  661 LETSRRGDMC DVKENI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) EHD3 MRP13 MRP21 MRPS18 MRPS9 PUS7 RSM26 RSM27 RSM7
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2006) PUS7 TAN1
    View Details Gavin AC, et al. (2002) ASC1 BEM2 CBF5 CCM1 CDC33 CIR2 DBP2 ECM16 EHD3 FYV4 GEP3 HEK2 HHF1, HHF2 HSC82 LHP1 MIS1 MRP1 MRP10 MRP13 MRP17 MRP21 MRP4 MRP51 MRP7 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 NAB6 NAM9 PAP2 PET123 POL2 PSD2 PUS7 RBG1 RIX1 ROM2 RSM10 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 SBP1 SNP1 SRO9 STM1 STO1 SUI3 TIF1, TIF2 TIF4631 TIF4632 UBP10 UTP20 UTP22 YMR310C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PUS7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] deduced N/A No confident structure predictions are available.
    2 View Details [118..607] Pfam 242.0 tRNA pseudouridine synthase D (TruD) No confident structure predictions are available.
    3 View Details [608..676] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  1.50596754488506 bayes_pls_golite062009
  • binding
    		•  1.49983036545301 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46911563206977 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.40070005217107 bayes_pls_golite062009
  • protein binding
    		•  0.491459233332405 bayes_pls_golite062009
  • catalytic activity
    		•  0.307971467423079 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.104498084588774 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle