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Protein Overview: NOC3

General Information:
Name(s) found: NOC3 / YLR002C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 663 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Noc2p-Noc3p complex [IPILink to PubMed article]
    nucleolus [TASLink to PubMed article]
    Biological Process: DNA replication initiation [IDALink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [IDALink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]
    chromatin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRNRSQFR IQERTAKKRK HEDSLLEGNV FQNAPEDMDE NTIYSAKGSS WDEEEQDYEM  60
   61 VPRKNRSDTS NLVEGLPIKV NGKVERKLHK AQEKPKDDDE EDEDSNDSSE DDEGPNEEQE 120
  121 AEAKEDEPDT EEKILQLKED IADLVTKVME EPEENTAALG RLCKMVESKN PNTCKFSMLA 180
  181 LVPVFKSIIP GYRIRPLTET EKKEKVSKEV SKLRNFEQAL VYNYKNYVGR LQSLSKTPSN 240
  241 AAPIQVSLGI LATQAAKELI STASHFNFRT DIFTLLLRRI CKPRISTDPT SIQIIQTFET 300
  301 LLNEDEEGSI SFEILRIFNK ILKTRNFNIE ESVLNMLLSL DVLHDYDPNT KLKGNVSAPK 360
  361 LKKKDRVHLS KKQRKARKEM QQIEEEMRNA EQAVSAEERE RNQSEILKIV FTIYLNILKN 420
  421 NAKTLIGSVL EGLTKFGNMA NFDLLGDFLE VMKELISDTE FDNLSSAEVR KALLCIVSAF 480
  481 SLISNTQYMK VNVDLSKFVD GLYALLPYIC LDADIELSYR SLRLADPLNN EIIKPSVNVS 540
  541 TKAELLLKAL DHVFFRSKSG TKERATAFTK RLYMCISHTP EKTSIAILKF IDKLMNRYPE 600
  601 ISGLYSSEDR IGNGHFIMEA DNPSRSNPEA ATLWDNALLE KHYCPVVTKG LRSLSSRSKE 660
  661 CSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BRX1 CIC1 DBP10 DRS1 EBP2 ERB1 FPR4 HAS1 MAK21 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP12 NOP15 NOP16 NOP2 NOP7 NSA1 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPF2 RPL15A RPL25 SPB4 TIF6 YTM1
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) ACO1 BRX1 CCT6 CDC14 CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 EBP2 EGD2 ENP2 ERB1 EXG1 FPR4 GDE1 GND1 GUS1 HAS1 HHF1, HHF2 HOT1 HXT7 KRI1 MET6 MRPL1 MRT4 MUB1 NOC2 NOC3 NOG1 NOP12 NOP15 NOP16 NOP2 NOP7 NSA1 NUG1 PDI1 PIB2 POB3 POL2 PRP43 PUF6 PWP1 RLP7 RRP14 RRP17 RRP5 SAH1 SCS2 SEC53 SFP1 SPB4 SPT16 SSF1 SSQ1 THI21 TIF4631 TIF6 TRL1 UBR2 UTP22 VMR1 VPS73 WTM2 YRA1 YTM1
    View Details Qiu et al. (2008) BRX1 DBP3 DBP6 DBP7 DRS1 ENP1 GAR1 KRR1 LTV1 MCM4 NOB1 NOC2 NOC3 NOP15 NUG1 PWP2 PXR1 SPB4 UTP5 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOC3 and NOP56 Huh WK, et al. (2003)
    View Data NOC3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..263] ORFEUS 9.86 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    3 View Details [264..329] ORFEUS 9.86 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    4 View Details [330..470] ORFEUS 9.86 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    5 View Details [471..663] ORFEUS 9.86 Constant regulatory domain of protein phosphatase 2a, pr65alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  3.36069436734718 bayes_pls_golite062009
  • binding
    		•  2.36800795249393 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67566088591721 bayes_pls_golite062009
  • structural molecule activity
    		•  1.49650156618775 bayes_pls_golite062009
  • protein binding
    		•  1.3800948965226 bayes_pls_golite062009
  • mRNA binding
    		•  1.35186555044783 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08645493064764 bayes_pls_golite062009
  • DNA binding
    		•  0.806448013051712 bayes_pls_golite062009
  • transcription factor activity
    		•  0.371244009721798 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle