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Protein Overview: TRL1

General Information:
Name(s) found: TRL1 / YJL087C [SGD]
Description(s) found:
Found 29 descriptions.
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  • tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 827 amino acids

    Gene Ontology:
    Cellular Component: nuclear inner membrane [IDALink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: UFP-specific transcription factor mRNA processing during unfolded protein response [TASLink to PubMed article]
    tRNA splicing, via endonucleolytic cleavage and ligation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [IDALink to PubMed article]
    2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [IDALink to PubMed article]
    RNA ligase (ATP) activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSPYDGKRT VTQLVNELEK AEKLSGRGRA YRRVCDLSHS NKKVISWKFN EWDYGKNTIT  60
   61 LPCNARGLFI SDDTTNPVIV ARGYDKFFNV GEVNFTKWNW IEENCTGPYD VTIKANGCII 120
  121 FISGLEDGTL VVCSKHSTGP RADVDRNHAE AGEKQLLRQL AAMNINRSDF ARMLYTHNVT 180
  181 AVAEYCDDSF EEHILEYPLE KAGLYLHGVN VNKAEFETWD MKDVSQMASK YGFRCVQCIT 240
  241 SNTLEDLKKF LDNCSATGSF EGQEIEGFVI RCHLKSTEKP FFFKYKFEEP YLMYRQWREV 300
  301 TKDYISNKSR VFKFRKHKFI TNKYLDFAIP ILESSPKICE NYLKGFGVIE LRNKFLQSYG 360
  361 MSGLEILNHE KVAELELKNA IDYDKVDERT KFLIFPISVI GCGKTTTSQT LVNLFPDSWG 420
  421 HIQNDDITGK DKSQLMKKSL ELLSKKEIKC VIVDRNNHQF RERKQLFEWL NELKEDYLVY 480
  481 DTNIKVIGVS FAPYDKLSEI RDITLQRVIK RGNNHQSIKW DELGEKKVVG IMNGFLKRYQ 540
  541 PVNLDKSPDN MFDLMIELDF GQADSSLTNA KQILNEIHKA YPILVPEIPK DDEIETAFRR 600
  601 SLDYKPTVRK IVGKGNNNQQ KTPKLIKPTY ISAKIENYDE IIELVKRCIA SDAELTEKFK 660
  661 HLLASGKVQK ELHITLGHVM SSREKEAKKL WKSYCNRYTD QITEYNNNRI ENAQGSGNNQ 720
  721 NTQVKTTDKL NFRLEKLCWD EKIIAIVVEL SKDKDGCIID ENNEKIKGLC CQNKIPHITL 780
  781 CKLESGVKAV YSNVLCEKVE SAEVDENIKV VKLDNSKEFV GSVYLNF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LOS1 SEN15 SEN2 SEN34 SEN54 STP1 STP2 STP3 STP4 TPT1 TRL1
    View Details Krogan NJ, et al. (2006) SAG1 TRL1 YJR124C YPL141C
    View Details Ho Y, et al. (2002) ADH2 CIC1 CKA1 CKA2 CKB1 CKB2 COP1 DBP10 DSS1 ENP2 GDE1 HHF1, HHF2 HOT1 KRI1 MAM33 MRPL1 NOC3 NOP12 NOP2 NOP7 PDI1 POB3 POL2 PUF6 PWP1 RRP14 RRP5 SFP1 SLD2 SPT16 SRP1 SSF1 TIF4631 TRL1 UTP22 VMR1 VPS73 WTM2 YRA1
    View Details Qiu et al. (2008) SEN15 SEN2 SEN34 SEN54 TRL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..307] MSA 1.004919 View MSA. No confident structure predictions are available.
    2 View Details [308..827] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle