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Protein Overview: RPG1

General Information:
Name(s) found: RPG1 / YBR079C [SGD]
Description(s) found:
Found 31 descriptions.
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  • eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 964 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    ribosome [TASLink to PubMed article]
    eukaryotic translation initiation factor 3 complex [IDALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Biological Process: translational initiation [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: translation initiation factor activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPPPFRPEN AIKRADELIS VGEKQAALQS LHDFITARRI RWATPSTVEP VVFKFLEIGV  60
   61 ELKKGKLLKD GLHQYKKLIQ GSTEGLVSVG AVARKFIDLV ESKIASEQTR ADELQKQEID 120
  121 DDLEGGVTPE NLLISVYESD QSVAGFNDEA ITSWLRFTWE SYRAVLDLLR NNALLEITYS 180
  181 GVVKKTMHFC LKYQRKNEFK RLAEMLRQHL DAANYQQSKS GNNLVDLSDA DTLQRYLDQR 240
  241 FQQVDVSVKL ELWHEAYRSI EDVFHLMKIS KRAPKPSTLA NYYENLVKVF FVSGDPLLHT 300
  301 TAWKKFYKLY STNPRATEEE FKTYSSTIFL SAISTQLDEI PSIGYDPHLR MYRLLNLDAK 360
  361 PTRKEMLQSI IEDESIYGKV DEELKELYDI IEVNFDVDTV KQQLENLLVK LSSKTYFSQY 420
  421 IAPLRDVIMR RVFVAASQKF TTVSQSELYK LATLPAPLDL SAWDIEKSLL QAAVEDYVSI 480
  481 TIDHESAKVT FAKDPFDIFA STASKEVSEE ENTEPEVQEE KEETDEALGP QETEDGEEKE 540
  541 EESDPVIIRN SYIHNKLLEL SNVLHDVDSF NNASYMEKVR IARETLIKKN KDDLEKISKI 600
  601 VDERVKRSQE QKQKHMEHAA LHAEQDAEVR QQRILEEKAA IEAKLEEEAH RRLIEKKKRE 660
  661 FEAIKEREIT KMITEVNAKG HVYIDPNEAK SLDLDTIKQV IIAEVSKNKS ELESRMEYAM 720
  721 KKLDHTERAL RKVELPLLQK EVDKLQETDT ANYEAMKKKI VDAAKAEYEA RMADRKNLVM 780
  781 VYDDYLKFKE HVSGTKESEL AAIRNQKKAE LEAAKKARIE EVRKRRYEEA IARRKEEIAN 840
  841 AERQKRAQEL AEATRKQREI EEAAAKKSTP YSFRAGNREP PSTPSTLPKA TVSPDKAKLD 900
  901 MIAQKQREME EAIEQRLAGR TAGGSSPATP ATPATPATPT PSSGPKKMTM AEKLRAKRLA 960
  961 KGGR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FUN12 GCD11 HCR1 NIP1 PRT1 RPG1 RPS8B, RPS8A SUI1 SUI2 TIF34 TIF35 TIF5 YEF3
    View Details (MIPS) Mewes HW, et al. (2004) GCD10 NIP1 PRT1 RPG1 SUI1 TIF34 TIF35
    View Details Krogan NJ, et al. (2006) ADE8 CHZ1 ECM2 HCR1 HEM12 KAP122 NIP1 PRT1 RPG1 SUI1 SYH1 TIF34 TIF35 TIF5 YOR052C
    View Details Gavin AC, et al. (2006) FUN12 HCR1 NIP1 PRT1 RLI1 RPG1 TIF34 TIF35 TIF5
    View Details Gavin AC, et al. (2002) ADA2 ADH1 ARX1 ASC1 ATG9 AVO1 BDF2 BEM2 BMS1 BRX1 BUD20 CAB3 CDC55 CEG1 CET1 CHD1 CIC1 CKA1 CKA2 CKB1 CKB2 CLU1 COG3 CSE2 CTR9 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 DYN1 EBP2 ECM5 ENO2 ERB1 FAB1 FBA1 FPR4 FUN12 GAL11 GCN1 GCN5 GLT1 GLY1 HAS1 HAT1 HAT2 HCR1 HDA1 HER1 HHF1, HHF2 HIF1 HIS3 HOT1 HSM3 ICL1 IML1 INP2 IPI1 IPI3 IST2 ISW1 ISW2 KAP123 KRE33 KTR5 LHP1 LIP2 LOC1 LSG1 LSM12 MAC1 MAK21 MAK5 MDN1 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MIS1 MLP1 MRPL6 MRT4 MSB1 NAP1 NIP1 NIP7 NMD3 NMD5 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 NUT1 NUT2 PDB1 PFK1 PGD1 PGK1 PRO1 PRP43 PRT1 PSD2 PSE1 PSH1 PUF6 REI1 RET1 RGR1 RIC1 RIX1 RIX7 RLI1 RLP24 RLP7 ROX3 RPA135 RPA190 RPC40 RPF1 RPF2 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPO21 RPP2B RPT2 RPT3 RPT5 RPT6 RRP1 RRP12 RSA3 RSA4 RSC3 RTR1 RVB2 SAM1 SDA1 SEC7 SIN4 SKI2 SNU13 SPB1 SPB4 SPT16 SPT5 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSA3 SSA4 SSE2 SSF1 SSN2 SSN3 SSN8 SUA7 SUI1 SUI2 SUI3 SUP45 TAF6 TEL1 TIF1, TIF2 TIF34 TIF35 TIF5 TIF6 TOP2 TSC11 TUB3 URB1 USO1 UTP10 UTP20 UTP22 UTP6 VPS1 VTH2 YFR006W YGL036W YIL077C YPR077C YTA7 YTM1
    View Details Ho Y, et al. (2002) ATP3 BEM2 COP1 DUF1 EDE1 FOL2 HTB2 LHS1 NIP1 POR1 RPG1 SES1 SRV2 SUI1 TIF34 TIF35 UBI4
    View Details Qiu et al. (2008) CLU1 FUN12 HCR1 NIP1 PRT1 RPG1 SUI3 TIF11 TIF3 TIF34 TIF35 TIF5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ALG13 No Comments Hazbun TR, et al. (2003)
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run RIX1 No Comments Hazbun TR, et al. (2003)
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RPG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] ORFEUS 11.47 Transcription factor MalT domain III
    2 View Details [159..285] ORFEUS 11.47 Transcription factor MalT domain III
    3 View Details [286..451] ORFEUS 11.47 Transcription factor MalT domain III
    4 View Details [452..521] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [522..610] PSI-BLAST 8.69897 Tropomyosin
    6 View Details [611..964] PSI-BLAST 13.0 Heavy meromyosin subfragment


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle