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Protein Overview: ADE8

General Information:
Name(s) found: ADE8 / YDR408C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 214 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: adenine biosynthetic process [TASLink to PubMed article]
    purine nucleotide biosynthetic process [TAS]
    'de novo' IMP biosynthetic process [TAS]
    Molecular Function: phosphoribosylglycinamide formyltransferase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARIVVLISG SGSNLQALID AQKQGQLGED AHIVSVISSS KKAYGLTRAA DNNIPTKVCS  60
   61 LYPYTKGIAK EDKAARAKAR SQFENDLAKL VLEEKPDVII CAGWLLILGS TFLSQLQSVP 120
  121 ILNLHPALPG CFDGTTHAIE MAWRKCQDEN KPLTAGCMVH YVIEEVDKGE PLVVKKLEII 180
  181 PGEETLEQYE QRVHDAEHIA IVEATYKVLQ QLHK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE8 CHZ1 ECM2 HCR1 HEM12 KAP122 NIP1 PRT1 RPG1 SUI1 SYH1 TIF34 TIF35 TIF5 YOR052C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ADE8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] PSI-BLAST 192.228787 Glycinamide ribonucleotide transformylase, GART
    2 View Details [115..214] PSI-BLAST 192.228787 Glycinamide ribonucleotide transformylase, GART

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.09881190860822 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.01667310557403 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  3.81159871979977 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  3.49010887242285 bayes_pls_golite062009
  • phosphoribosylglycinamide formyltransferase activity
    		•  2.94311083909314 bayes_pls_golite062009
  • methionyl-tRNA formyltransferase activity
    		•  2.39150724300118 bayes_pls_golite062009
  • catalytic activity
    		•  2.16003793103722 bayes_pls_golite062009
  • binding
    		•  1.1813924954238 bayes_pls_golite062009
  • transferase activity
    		•  1.01502594768782 bayes_pls_golite062009
  • ligase activity
    		•  0.922788719307786 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle