YRC Public Data Repository - Protein Structure Prediction

Protein:	ADE8
Organism:	Saccharomyces cerevisiae
Length:	214 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE8.

Description	E-value	Query Range	Subject Range
gi\|68649, gi\|157... - pir\|\|AJFFPM phosphoribosylamine-glycine ligase (EC 6.3.4.13) - fruit fly (Drosophila melanogaster),...	2.0E-52	[2..213]	[1154..1344]
PUR2_CHITE - Trifunctional purine biosynthetic protein adenosine-3 OS=Chironomus tentans GN=GART PE=3 SV=1	1.0E-50	[2..211]	[1170..1358]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-50	[3..211]	[809..994]
gi\|691792, gi\|68... - gi\|691792\|gb\|AAC53251.1\| glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthet...	3.0E-50	[3..211]	[809..994]
PUR2_DROPS - (P16340) Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glyci...	1.0E-49	[2..203]	[1156..1336]
gi\|1772500\|emb\|C... - Met-tRNAi formyl transferase [Bacillus subtilis] gi\|1772500 - gi\|1772500\|emb\|CAA71350.1\| Met-tRNAi formyl transferase [Bacillus subtilis]	1.0E-49	[1..212]	[1..188]
gi\|229898970, gi... - gi\|229898970\|ref\|ZP_04514114.1\| phosphoribosylglycinamide formyltransferase 1 [Yersinia pestis biova... gi\|166960781, gi... - gi\|167421292\|ref\|ZP_02313045.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar ... gi\|167398688, gi... - gi\|167398688\|ref\|ZP_02304212.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar ... gi\|167467157 - gi\|167467157\|ref\|ZP_02331861.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis FV-1] gi\|167424704, gi... - gi\|167424704\|ref\|ZP_02316457.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar ... gi\|186699229, gi... - gi\|186896203\|ref\|YP_001873315.1\| phosphoribosylglycinamide formyltransferase [Yersinia pseudotubercu... gi\|170023592, gi... - gi\|170023592\|ref\|YP_001720097.1\| phosphoribosylglycinamide formyltransferase [Yersinia pseudotubercu... gi\|25528242 - pir\|\|AG0344 probable phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) [imported] - Yersinia ... gi\|45442471, gi\|... - gi\|45442471\|ref\|NP_994010.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar Mic... gi\|162351086, gi... - gi\|77636346\|ref\|ZP_00798421.1\| COG0299: Folate-dependent phosphoribosylglycinamide formyltransferase... gi\|149365294, gi... - gi\|149365294\|ref\|ZP_01887329.1\| putative phosphoribosylglycinamide formyltransferase [Yersinia pesti... gi\|21958181, gi\|... - gi\|22125304\|ref\|NP_668727.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis KIM], gi\|2... gi\|117672935, gi... - gi\|77629839\|ref\|ZP_00792425.1\| COG0299: Folate-dependent phosphoribosylglycinamide formyltransferase... gi\|145211149, gi... - gi\|145599453\|ref\|YP_001163529.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis Pestoi... gi\|165926025, gi... - gi\|165926025\|ref\|ZP_02221857.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar ... gi\|16123026, gi\|... - gi\|218929894\|ref\|YP_002347769.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis CO92],... gi\|166206413, gi... - gi\|166212482\|ref\|ZP_02238517.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar ... gi\|165992570, gi... - gi\|166008188\|ref\|ZP_02229086.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis biovar ... gi\|229681662, gi... - gi\|229901733\|ref\|ZP_04516855.1\| phosphoribosylglycinamide formyltransferase 1 [Yersinia pestis Nepal... gi\|165937014, gi... - gi\|89104925\|ref\|ZP_01177455.1\| COG0299: Folate-dependent phosphoribosylglycinamide formyltransferase... gi\|229838403, gi... - gi\|229838403\|ref\|ZP_04458562.1\| phosphoribosylglycinamide formyltransferase 1 [Yersinia pestis biova... gi\|108780173, gi... - gi\|108808260\|ref\|YP_652176.1\| phosphoribosylglycinamide formyltransferase [Yersinia pestis Antiqua],... gi\|229701546, gi... - gi\|229895391\|ref\|ZP_04510563.1\| phosphoribosylglycinamide formyltransferase 1 [Yersinia pestis Pesto...	2.0E-49	[1..211]	[1..188]
FMT_CLOAB - Methionyl-tRNA formyltransferase OS=Clostridium acetobutylicum GN=fmt PE=3 SV=2 FMT_CLOAB - Methionyl-tRNA formyltransferase OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419...	3.0E-49	[1..214]	[1..190]
FMT_CLOPE - Methionyl-tRNA formyltransferase OS=Clostridium perfringens GN=fmt PE=3 SV=1 FMT_CLOPE - Methionyl-tRNA formyltransferase OS=Clostridium perfringens (strain 13 / Type A) GN=fmt PE=3 SV=1	5.0E-49	[3..211]	[2..186]
PUR2_CHICK - Trifunctional purine biosynthetic protein adenosine-3 OS=Gallus gallus GN=GART PE=2 SV=1	5.0E-49	[3..211]	[805..990]

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Predicted Domain #1

Region A:
Residues: [1-114]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARIVVLISG SGSNLQALID AQKQGQLGED AHIVSVISSS KKAYGLTRAA DNNIPTKVCS  60
   61 LYPYTKGIAK EDKAARAKAR SQFENDLAKL VLEEKPDVII CAGWLLILGS TFLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	192.228787
Match:	1c3eA_
Description:	Glycinamide ribonucleotide transformylase, GART
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.09881190860822	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.01667310557403	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	3.81159871979977	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	3.49010887242285	bayes_pls_golite062009
phosphoribosylglycinamide formyltransferase activity	2.94311083909314	bayes_pls_golite062009
methionyl-tRNA formyltransferase activity	2.39150724300118	bayes_pls_golite062009
catalytic activity	2.16003793103722	bayes_pls_golite062009
binding	1.1813924954238	bayes_pls_golite062009
transferase activity	1.01502594768782	bayes_pls_golite062009
ligase activity	0.922788719307786	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [115-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLQSVPILNL HPALPGCFDG TTHAIEMAWR KCQDENKPLT AGCMVHYVIE EVDKGEPLVV  60
   61 KKLEIIPGEE TLEQYEQRVH DAEHIAIVEA TYKVLQQLHK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	192.228787
Match:	1c3eA_
Description:	Glycinamide ribonucleotide transformylase, GART
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: