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Protein Overview: NOP15

General Information:
Name(s) found: NOP15 / YNL110C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 220 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: cytokinesis, actomyosin contractile ring assembly [IMPLink to PubMed article]
    ribosomal large subunit biogenesis [IMPLink to PubMed article][IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    ribosome assembly [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKSTSKTST KETVTKQPTE EKPIQEKEEL ALETSSSSSD EEDEKDEDEI EGLAASDDEQ  60
   61 SGTHKIKRLN PKKQANEKKS KDKKTLEEYS GIIYVSRLPH GFHEKELSKY FAQFGDLKEV 120
  121 RLARNKKTGN SRHYGFLEFV NKEDAMIAQE SMNNYLLMGH LLQVRVLPKG AKIEKLYKYK 180
  181 KRVLVEKGIT KPVKQLKDNM KQKHEERIKK LAKSGIEFKW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BRX1 CIC1 DBP10 DRS1 ERB1 HAS1 IPI3 MAK21 MDN1 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPF2 RPL25 SDA1 SPB1 SPB4 TIF6 YTM1
    View Details Krogan NJ, et al. (2006) NOG1 NOG2 NOP15 NUG1 YSW1
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) ACO1 BRX1 CIC1 DNL4 EBP2 ERB1 EXG1 FPR4 GDE1 HTA1 KGD1 MAK16 MRT4 NOC3 NOG1 NOP15 NOP16 NOP2 NOP7 NSA1 PIB2 RLP7 RPF2 RRP17 RRT6 SCS2 THI21 TIF6 YTM1
    View Details Qiu et al. (2008) BRX1 DBP3 DBP7 DBP8 DHR2 DRS1 FAL1 FCF2 GAR1 HCA4 KRE33 KRR1 MAK11 MAK5 MRT4 NOC3 NOP12 NOP13 NOP15 NOP16 NOP4 NOP7 NSR1 NUG1 PUF6 PXR1 RCL1 RPL15B RPL27A RPL7B RRP3 RRP9 SLX9 SOF1 SPB4 SSF1 UTP13 UTP15 UTP4 UTP8 UTP9 YBL028C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOP15 Huh WK, et al. (2003)
    View Data NOP15 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 94.751666 Hu antigen D (Hud)
    2 View Details [87..220] PSI-BLAST 94.751666 Hu antigen D (Hud)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.30964910634891 bayes_pls_golite062009
  • binding
    		•  3.49612884560266 bayes_pls_golite062009
    		• 2.46776845687856 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34356093608328 bayes_pls_golite062009
  • structural molecule activity
    		•  2.3267948877508 bayes_pls_golite062009
  • mRNA binding
    		•  2.24051526954235 bayes_pls_golite062009
  • protein binding
    		•  1.32954276279597 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.12523515831597 bayes_pls_golite062009
  • ribosomal large subunit binding
    		•  0.13509933485234 bayes_pls_golite062009
  • snoRNA binding
    		•  0.0568636182001701 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.0260497600770142 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle