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Protein Overview: GCN1

General Information:
Name(s) found: GCN1 / YGL195W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2672 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of translational elongation [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAILNWEDI SPVLEKGTRE SHVSKRVPFL QDISQLVRQE TLEKPQLSEI AFVLLNTFTI  60
   61 YEDNRSKSLV TSILLDILNL EPCLLENFIR FISDVVISNP ATKAVADYLN LLDWINSFLI 120
  121 FVSHNSNLFE EYIPKLLVAH SYATFGVETI LDNQEEGKKS QDKQNQHRKR IRYCIFQTTV 180
  181 KAFLKCLKDN DDSISFMKIS IKTVLESYSK LKITSVGVVM IMGALTQAAL QLLSRQPALH 240
  241 SVLKENSAEK YCEYLGKEVF LGKNPPSSFC LEIGLKPFLK EFVSQELFIK FFIPNIEKAV 300
  301 LRSPEVGFSI LSELYAGVSP EKVNLLNAFA SSKLINQYFS SFKSSKEVVR SVSLQSMIIL 360
  361 LRKISNTDTT LEDLTKLIDE IFKNIKSNLN ADYKSLISKI LIEIPLTHYE VSEKICKGLS 420
  421 PYIGKEGNEA ALTLMLNAFF VHYFSLGKPI EDLDKIISAG FADKKPALKK CWFAAFLNNS 480
  481 NAASEEVILN FIDGCLEFVK DSIIHYQTHG HACILASIEF TNKILALDNT ELNDRVMQLI 540
  541 ETLPENSSIG DAILTAALST ELSIENRIHA VNLLQELFYK KPEFIGFSVI DAIERRMRVQ 600
  601 ELIPQQNTSF KYVTSVLLAI TSELPDKEAS IKVLINALVI AQWNIFNIKN GWAGLVLRAR 660
  661 LDPAEVVKEH ASVIMEKILE ITGSCEWIDT IYGACGLQAA AYAAFIQPNE FTPILCKTIE 720
  721 ADLTADDFSR LSEEDFEIFA GEEGVLVVDV LEESMNKKLS NKNSKEYETL MWEQKIRKEQ 780
  781 AKKNVKKLSK EEQELVNEQL AKESAVRSHV SEISTRLKRG IRLVSELSKA ACLVQNGIAT 840
  841 WFPLAVTKLL YLCSEPNISK LTEDVNNVFL QLSQNVSERL GNIRLFLGLA TLRVHNANGI 900
  901 SQDYLQEPLV ELLTRVLFRI KFVSNQAAID SISLTYILPL LINVLEKGKA IALKNADKPV 960
  961 VKAEFVEEDE EEEHLLLAME IISVHAEAFE DPSIPRISIV EVLLSLLSLP SKAKIAKDCF1020
 1021 NALCQSISVA PNQEDLDMIL SNLLSPNQFV RSTILETLDN EFELEPFMKY SPEVFICRFD1080
 1081 SDPSNREIAD FIWEFNKFVV NDELLKSLFP LFNQDDSGLR LFAANAYAFG AVSLFTSEEN1140
 1141 SSKDYLNDLL NFYKEKAKPL EPILDQFGLV LVSASEQKDP WQGRSTVAIT LKIMAKAFSA1200
 1201 EDDTVVNIIK FLVDDGGLVD REPIVRQEMK EAGVELITLH GSQNSKDLIP IFEEALSSST1260
 1261 DSALKENVII LYGTLARHLQ QSDARIHTII ERLLSTLDTP SADIQQAVSA CIAPLVFQFK1320
 1321 QKVGDYLGIL MEKLLNPTVA SSMRKGAAWG IAGLVKGYGI SALSEFDIIR NLIEAAEDKK1380
 1381 EPKRRESVGF CFQYLSESLG KFFEPYVIEI LPNILKNLGD AVPEVRDATA RATKAIMAHT1440
 1441 TGYGVKKLIP VAVSNLDEIA WRTKRGSVQL LGNMAYLDPT QLSASLSTIV PEIVGVLNDS1500
 1501 HKEVRKAADE SLKRFGEVIR NPEIQKLVPV LLQAIGDPTK YTEEALDSLI QTQFVHYIDG1560
 1561 PSLALIIHII HRGMHDRSAN IKRKACKIVG NMAILVDTKD LIPYLQQLID EVEIAMVDPV1620
 1621 PNTRATAARA LGALVERLGE EQFPDLIPRL LDTLSDESKS GDRLGSAQAL AEVISGLGLT1680
 1681 KLDEMLPTIL AGVTNFRAYI REGFMPLLLF LPVCFGSQFA PYINQIIQPI LSGLADNDEN1740
 1741 IRDTALKAGK LIVKNYATKA VDLLLPELER GMFDENDRIR LSSVQLTGEL LFQVTGISSR1800
 1801 NEFSEEDGDH NGEFSGKLVD VLGQDRRDRI LAALFVCRND TSGIVRATTV DIWKALVPNT1860
 1861 PRAVKEILPT LTGMIVTHLA SSSNVLRNIA AQTLGDLVRR VGGNALSQLL PSLEESLIET1920
 1921 SNSDSRQGVC IALYELIESA STETISQFQS TIVNIIRTAL IDESATVREA AALSFDVFQD1980
 1981 VVGKTAVDEV LPYLLHMLES SDNSDFALLG LQEIMSKKSD VIFPILIPTL LAPPIDAFRA2040
 2041 SALGSLAEVA GSALYKRLSI IINALVDAII GTSEDESTKG ALELALDRVF LSVNDDEGLH2100
 2101 PLLQQIMSLL KSDNIEKRIA VLERLPNFFD KTVLDFDVYI PNFVSHAILS LDDEDQRVVN2160
 2161 GNFNALSTLL KKVDKPTLEK LVKPAKQSLA LTGRQGQDVA AFKLPRGPNC VLPIFLHGLM2220
 2221 YGSNDEREES ALAIADVVSK TPAANLKPFV SVITGPLIRV VGERFSSDIK AAILFALNVL2280
 2281 FIKIPMFLRP FIPQLQRTFV KSLSDATNET LRLRAAKALG ALIEHQPRVD PLVIELVTGA2340
 2341 KQATDEGVKT AMLKALLEVI MKAGSKLNEN SKTNIVNLVE EEMLGSNDKL AVAYAKLIGS2400
 2401 LSEILSNDEA HKILQDKVLN ADLDGETGKF AILTLNSFLK DAPTHIFNTG LIDEFVSYIL2460
 2461 NAIRSPDVYF GENGTIAAGK LLLLEGEKRS PFVKKDAAEP FKIGDENINL LINELSKAVL2520
 2521 QPASNSTDVR RLALVVIRTL ARFKFDECIK QYFDVVGPSV FSCLRDPVIP IKLAAEKAYL2580
 2581 ALFKLVEEDD MHTFNEWFAK ISDRGNSIET VTGTTIQLRS VGDYTKRVGK RLANVERERI2640
 2641 AAGGDAETMF SDRFEDEREI WAVGGVELTT DI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GCN1 GCN20 RSA4 UTP14 YHL039W
    View Details Gavin AC, et al. (2006) GCN1 GCN20
    View Details Gavin AC, et al. (2002) ACT1 ADE4 ADH1 AHA1 ARX1 ASC1 ATP11 BEM2 BFR2 BMH1 BMH2 BMS1 BRX1 BUD20 BUD21 CAF130 CAF40 CBF5 CCR4 CCT4 CCT6 CCT8 CDC36 CDC39 CFT2 CHC1 CIC1 CKA1 CKA2 CKB1 CKB2 CLU1 CMD1 CMS1 COP1 CRM1 CSE1 CSL4 CTR9 CYR1 CYS4 DBP10 DBP8 DBP9 DCP2 DHH1 DIA4 DIM1 DIP2 DIS3 DRS1 DUG1 EBP2 ECM1 ECM16 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESC8 ESF1 ESF2 FAP7 FAS2 FIP1 FKS1 FPR4 GCN1 GCN20 GEA2 GFA1 GGA2 GLC7 HAS1 HCA4 HDA1 HER1 HHF1, HHF2 HIS3 HRP1 HSC82 HSL1 HTA2 IDH2 IMP3 IMP4 INP2 IOC3 IPI1 IPI3 IRR1 ISW1 ITC1 KAP104 KAP114 KAP123 KRE33 KRR1 KTR3 LCB1 LCB2 LCP5 LHP1 LOC1 LSG1 LTV1 LYS12 LYS2 MAK21 MAK5 MAM33 MCD1 MDN1 MET18 MIR1 MIS1 MLC1 MLC2 MOT1 MOT2 MPP10 MRD1 MRT4 MTR3 MTR4 MVD1 MYO1 MYO2 MYO4 NAB2 NAB3 NAN1 NAP1 NIP1 NIP7 NMD3 NMD5 NOB1 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NOT3 NOT5 NPL6 NSA1 NSA2 NUG1 PAP1 PDC1 PFK2 PFS2 PNO1 POL1 POL12 POP2 PRE6 PRE9 PRI1 PRI2 PRP43 PRT1 PSE1 PTA1 PTI1 PUF6 PWP2 RAD3 RCL1 REF2 REI1 RGR1 RIX1 RIX7 RLP24 RLP7 RML2 RNA14 ROK1 RPA135 RPA190 RPC40 RPF1 RPF2 RPG1 RPN10 RPN9 RPP2B RPT3 RPT5 RPT6 RRP1 RRP12 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 RRP7 RRP9 RSA3 RSA4 RSC2 RSC4 RSC58 RSC6 RSC8 RTG2 RTR1 RVB2 SAM1 SAM2 SCC4 SCL1 SDA1 SEC21 SEC27 SEC7 SHE2 SHE3 SHE4 SIN3 SKI2 SKI6 SKI7 SLC1 SLX9 SMC1 SMC3 SNU13 SOF1 SPB1 SPB4 SPT15 SRO9 SRP1 SRV2 SSF1 SXM1 TAF1 TAF5 TAF6 TFC7 TFP1 TIF1, TIF2 TIF6 TSR1 TUB3 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YDJ1 YEF3 YGL036W YHB1 YHR020W YOR059C YRA1 YSH1 YTM1
    View Details Ho Y, et al. (2002) ADR1 AIM46 AIP1 ATP4 BBC1 CDC39 CDC53 COF1 CRM1 CYR1 DUR1,2 ECM29 ECM33 FAA4 GAL3 GCN1 GSP1 GSP2 HRT1 HXT7 HYP2 KAP114 KAP95 LEM3 LOS1 MDN1 MKT1 MMS1 MYO2 NMD5 NUS1 PFK1 PHO81 PMA1 PMA2 POL5 REX2 RPA190 RPN1 RVB1 SEC7 SRV2 TCP1 TMA19 TOS3 TPS1 UBA1 UBC6 UBI4 UTP20 VPS13 YAR009C YGP1 YLR035C-A YLR326W YPT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run YJR012C No Comments Hazbun TR, et al. (2003)
    View Run SMC5 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GCN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] deduced N/A No confident structure predictions are available.
    2 View Details [192..482] MSA 2.007993 View MSA. No confident structure predictions are available.
    3 View Details [483..967] deduced N/A No confident structure predictions are available.
    4 View Details [968..1695] MSA 19.461998 View MSA. No confident structure predictions are available.
    5 View Details [1696..1809] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [1810..2151] MSA 4.253988 View MSA. No confident structure predictions are available.
    7 View Details [2152..2588] MSA 8.169996 View MSA. No confident structure predictions are available.
    8 View Details [2589..2672] deduced N/A Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.36

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle