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Protein Overview: ITC1

General Information:
Name(s) found: ITC1 / YGL133W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1264 amino acids

    Gene Ontology:
    Cellular Component: chromatin accessibility complex [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter by pheromones [IMPLink to PubMed article]
    chromatin remodeling [TASLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLYKRKPIL LPDPKPLPLD LNVQVWHIEE TGEWFSSYEE FLERFDFYTR HHFTCEITGT  60
   61 SCLTFFQALD SEETQFKYVE DRFPLKLREP VARFLHFNGI RRLDALVEKV YARFKNDFFP 120
  121 GEVVYLRKQK DSSTTSSNSQ QSTPQPDDMV EINSVGNPGL PQYQYQRRYV IKEKVQFNAT 180
  181 INPESREIVM PAHTKYMLIE EAASSNKSFI VDQGQIYRDR STFTKHLIKC FFKITLQRAS 240
  241 SKMGAPWCVK PEYLAMYGLT MEWPKDMLKY KEDEPVVARR SNSANVSSPE SEKNKRQSKS 300
  301 SGKSNTSNDA SNKKETKKKR KPTEVNDSEN NSSEEDKKKG QNVTSETHSK KRKKEANEEP 360
  361 NTENVESVPT PANAEPQAVT ITSIMDDLAL PYQHPPNIFP NLTYYNEKLE CISLGSTKLS 420
  421 RPFDSFGKLL QAYQFLNTFG SKICLSHFSL DQFITSLKCT DPYELKGEVV LVNIRTQTSK 480
  481 EQEIENNGLP MKNKAETTTE EDSENPSDWQ RNSFIRDMIM KRNSDKVEYK IVHDDPASDD 540
  541 ILDNINHNGS ALLIEVFTAL LRLFINEEGD WSCIVVENWI IDDKGVLMER KDERGEGEAK 600
  601 QKRNAHGYFL QDKEKIDNLK DTLKENATEV QKESDAKNET NSESDSKSDS DSEERDPKLE 660
  661 KCLNYRNVNW IERLTKRQFN NSYWLIILLG VLEDCRHLPM YTEFIDSFIE KIIPKDISAT 720
  721 QLPKQLWRNF CRKLSFSDKV NALWILVDLV SHFSPDIKAA VDDSMELCGQ IRSERFKVAR 780
  781 ELKTEAAVLS NLQGDLQAIQ EKLNKTDENT PSADGADKKD DSESNSEPID LIIIEKKQKL 840
  841 IEEQDKKVQA LQSDKNFLDN CLFENDLQRL KPLGLDRYGN RYFWLDHNGV PFPQYPAGMN 900
  901 ETPKSNNSLS YHSGRLLIQG PKASSAKFFL NVSDEQLSNW QKIRNSEGIS EATREVFGIS 960
  961 KTSSGSYNYV ENGIEVELLD SNDRVNPLIE LTPIQKKIMD ETPSRLLLSP DQWYCIDKLE1020
 1021 DLSRIMDWLD NWGRKEHDLL RQIRPIMERI KSSLSLRDHA LSLTAFTKNE EKLLKELENN1080
 1081 EFTENELNVD SMDVDDKNSG VKSEVDVQVD AEEKREAVID EKLEVIADEL MKLDDSSKTR1140
 1141 NVLNRIQELE DQRDELLEQK KSIINSQRPG ARILARSERK RTKISRGNKV NKQIEILTDL1200
 1201 VNYRHFKAME DVIAWKNVLA NSIWGSSLRK NASGNKRSGV IETVDDKLKD IVGQTSRTVT1260
 1261 PAPN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) IOC3 ISW1 ISW2 ITC1 MOT1 RSC2 RSC8 STH1 VPS1
    View Details Krogan NJ, et al. (2006) DLS1 ELA1 ISW2 ITC1
    View Details Gavin AC, et al. (2002) ACT1 ADE5,7 ADH1 ARP4 ARP8 ESC8 GCN1 HHF1, HHF2 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 MOT1 NHP10 NPL6 PDC1 REB1 RFA1 RFX1 RNR2 RPC34 RPC40 RPO31 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RVB2 SFH1 SIN3 SPT15 STH1 STO1 TAF1 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8 TOP1 VPS1 YBR090C-A, NHP6B
    View Details Qiu et al. (2008) ISW2 ITC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ITC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] deduced N/A No confident structure predictions are available.
    2 View Details [120..413] MSA 7.037996 View MSA. No confident structure predictions are available.
    3 View Details [414..506] Pfam 26.853872 DDT domain No confident structure predictions are available.
    4 View Details [507..1264] deduced N/A No confident structure predictions are available.
    5 View Details [487..656] deduced N/A No confident structure predictions are available.
    6 View Details [657..1264] FFAS03 1.29 No description for 2oevA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle