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Protein Overview: TFC8

General Information:
Name(s) found: TFC8 / YPL007C [SGD]
Description(s) found:
Found 32 descriptions.
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  • One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 588 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIIC complex [TASLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase III promoter [TASLink to PubMed article]
    Molecular Function: RNA polymerase III transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLLKDLLVD RKEFEDWKNN LTWARDGTLY LTTFPDISIG QPKYAKDINC NSKNLFHVKE  60
   61 FPLEFENKLD FELAQQNGLL NSQPVCYPRV CKPSPIDDWM AVLSNNGNVS VFKDNKMLTN 120
  121 LDSKGNLSSR TYHCFEWNPI ESSIVVGNED GELQFFSIRK NSENTPEFYF ESSIRLSDAG 180
  181 SKDWVTHIVW YEDVLVAALS NNSVFSMTVS ASSHQPVSRM IQNASRRKIT DLKIVDYKVV 240
  241 LTCPGYVHKI DLKNYSISSL KTGSLENFHI IPLNHEKEST ILLMSNKTSY KVLLEDELHV 300
  301 TADNIIAPYL EKKFKKWSTI WNEFNNYETT LVIHGISLSP DGYSIAIVYD MERVAFKYKI 360
  361 ASEQSFNIMF APLYHTWTIS ERAVGLAWYQ TYQIYNQSLP KLPENFSMNK KLLNGNYPIS 420
  421 LDFQSYLNAL MKSEEMRIIM FLNMTIDKPS ILSFLEALYE YAINKKSELT NSFDLACVLS 480
  481 IAAILKREAP IYNGTLLMKN SFLEETFNLE SFTADPETVT STTNNTWKRC GVTLLPILTT 540
  541 HVKICPVSKQ RVIDIKRDDL NDYGWFTRGL LERFNEISVY CGTTLEVM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Krogan NJ, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2002) ITC1 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Qiu et al. (2008) BDP1 BRF1 PZF1 SPT15 TAF14 TFA1 TFB5 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TFC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..588] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle