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Protein Overview: TFC6

General Information:
Name(s) found: TFC6 / YDR362C [SGD]
Description(s) found:
Found 29 descriptions.
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  • One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 672 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIIC complex [TASLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase III promoter [TASLink to PubMed article]
    Molecular Function: RNA polymerase III transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVIPAKKRG RPRKSVVAEV PYDSLASPVS ENSGSKRPRR NASKKAVANF AQLVHAGRDD  60
   61 VINTTQVNNV DDTDDDDFVL NDEGDGEESD NVEIEFENEL ESTKNEVADL NSSGSGASVR 120
  121 PSGRRNTVQK LRLKKNSTKN MKSSSPGSSL GQKGRPIRLL KDLSSARDKI ERIYGLNKEK 180
  181 LLLLAKVKEG FETSVFDFPF KNIQPDSPYF VCLDPPCKKE SAYNKVIGDK NRTVYHEINK 240
  241 TEFENMIKLR TKRLKLLIGE VDAEVSTGDK IEFPVLANGK RRGFIYNVGG LVTDIAWLNI 300
  301 EENTDIGKDI QYLAVAVSQY MDEPLNEHLE MFDKEKHSSC IQIFKMNTST LHCVKVQTIV 360
  361 HSFGEVWDLK WHEGCHAPHL VGCLSFVSQE GTINFLEIID NATDVHVFKM CEKPSLTLSL 420
  421 ADSLITTFDF LSPTTVVCGF KNGFVAEFDL TDPEVPSFYD QVHDSYILSV STAYSDFEDT 480
  481 VVSTVAVDGY FYIFNPKDIA TTKTTVSRFR GSNLVPVVYC PQIYSYIYSD GASSLRAVPS 540
  541 RAAFAVHPLV SRETTITAIG VSRLHPMVLA GSADGSLIIT NAARRLLHGI KNSSATQKSL 600
  601 RLWKWDYSIK DDKYRIDSSY EVYPLTVNDV SKAKIDAHGI NITCTKWNET SAGGKCYAFS 660
  661 NSAGLLTLEY LS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details (MIPS) Mewes HW, et al. (2004) TFC1 TFC3 TFC4 TFC6 TFC7
    View Details Krogan NJ, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2006) TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Gavin AC, et al. (2002) ITC1 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8
    View Details Qiu et al. (2008) BDP1 BRF1 PZF1 TFB5 TFC1 TFC3 TFC4 TFC6 TFC7 TFC8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TFC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..306] deduced N/A No confident structure predictions are available.
    2 View Details [307..672] ORFEUS 14.02 Tup1, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle