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Protein Overview: RSC8

General Information:
Name(s) found: RSC8 / YFR037C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 557 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    RSC complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    Biological Process: ATP-dependent chromatin remodeling [IDALink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTEKDKDV PMVDSHEATE EPPTTSTNTP SFPHLAQEQA KEESATLGAE VAHKKINYEQ  60
   61 EAQKLEEKAL RFLAKQTHPV IIPSFASWFD ISKIHEIEKR SNPDFFNDSS RFKTPKAYKD 120
  121 TRNFIINTYR LSPYEYLTIT AVRRNVAMDV ASIVKIHAFL EKWGLINYQI DPRTKPSLIG 180
  181 PSFTGHFQVV LDTPQGLKPF LPENVIKQEV EGGDGAEPQV KKEFPVNLTI KKNVYDSAQD 240
  241 FNALQDESRN SRQIHKVYIC HTCGNESINV RYHNLRARDT NLCSRCFQEG HFGANFQSSD 300
  301 FIRLENNGNS VKKNWSDQEM LLLLEGIEMY EDQWEKIADH VGGHKRVEDC IEKFLSLPIE 360
  361 DNYIREVVGS TLNGKGGDSR DGSVSGSKLM ECVNDAVQTL LQGDDKLGKV SDKSREISEK 420
  421 YIEESQAIIQ ELVKLTMEKL ESKFTKLCDL ETQLEMEKLK YVKESEKMLN DRLSLSKQIL 480
  481 DLNKSLEELN VSKKLVLISE QVDSGIQLVE KDQEGDDEDG NTATGHGVKR VGKEGEEVGE 540
  541 GDSIAKLQPQ VYKPWSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABF2 ARP7 ARP9 HHF1, HHF2 HTA2 HTB1 HTL1 IOC3 ISW1 ISW2 ITC1 MOT1 NFI1 NPL6 RFA1 RPC34 RSC1 RSC2 RSC3 RSC30 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 VPS1
    View Details (MIPS) Mewes HW, et al. (2004) ARP7 ARP9 RSC1 RSC2 RSC4 RSC6 RSC8 SAS5 SFH1 STH1
    View Details Krogan NJ, et al. (2006) ARP7 ARP9 ATG16 CSH1 GRS2 HTL1 MGR1 NFI1 NPL6 PCL9 RIM15 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 URC2 YIL177C
    View Details Gavin AC, et al. (2006) ARP7 NPL6 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 SFH1 STH1
    View Details Gavin AC, et al. (2002) ABF2 ACT1 ADE5,7 ADH1 AMS1 ARP4 ARP8 ASC1 CDC14 CKA1 CKA2 CKB1 CKB2 CMR1 CTI6 DEP1 DHH1 DNA2 DOT6 EAF3 ECM16 ESC8 FBA1 GCN1 HDA1 HDA2 HDA3 HHF1, HHF2 HSC82 HTA2 IES1 IES5 INO80 IOC3 ISW1 ISW2 ITC1 KAP95 LCD1 MAF1 MEC1 MED4 MGM101 MLH1 MOT1 MPH1 MSH2 MSH3 MSH6 NHP10 NPL6 NRD1 OLA1 PDC1 PGK1 PHO23 PMS1 PRO2 RAD16 RAD52 RCO1 REB1 RET1 RFA1 RFA2 RFA3 RFX1 RIM1 RNH1 RNR2 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPD3 RPO26 RPO31 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RVB2 RXT2 RXT3 SAP30 SDS3 SFH1 SGS1 SHS1 SIN3 SPT15 SRO7 STH1 STO1 TAF1 TFC7 TIF1, TIF2 TOP1 TOP3 TUP1 UME1 UME6 VAS1 VPS1 YBR090C-A, NHP6B YHR122W
    View Details Qiu et al. (2008) ARP7 ARP9 RSC1 RSC2 RSC4 RSC6 RSC8 SFH1 STH1 TAF14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RSC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] MSA 5.026974 View MSA. No confident structure predictions are available.
    2 View Details [178..247] deduced N/A No confident structure predictions are available.
    3 View Details [248..304] Pfam 21.853872 Zinc finger, ZZ type No confident structure predictions are available.
    4 View Details [305..358] PSI-BLAST 2.30103 v-Myb
    5 View Details [359..431] PSI-BLAST 7.0 Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
    6 View Details [432..557] PSI-BLAST 7.0 Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.40569731991064 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • ligase activity
    		•  2.30828657077565 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.29312770004164 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.11206038007886 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.3853719864144 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.90321253993065 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.350170315296021 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.255669498391574 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription activator activity
    		•  0.126093965701234 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.024993043379745 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle