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Protein Overview: RIM15

General Information:
Name(s) found: RIM15 / YFL033C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1770 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of meiosis [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    age-dependent response to oxidative stress involved in chronological cell aging [IMPLink to PubMed article]
    response to stress [IMPLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNRSNTAGG SQAMKEGLGI NKLSPISSNS NPSSLTSSNY EKYLQLATEK NPCMILELEL  60
   61 DGKVRYGSPQ WNTITGVADD SGSSPTYIAD LILGSDQDKG VFQKATDMLL MNDDTSCTIT 120
  121 FKIKAADYEG SAGCDDESTI TTLEARGILI RDGHTQLPSH TMWIVKPRTN DWSDFYANED 180
  181 AQDDMVIQLS DNCDDIDIQL PEEFAKTLGF GAKIFVQYLK RIRLEMIIDE FNLPLPKMEL 240
  241 CRVCENFVPV WWLETHSQSC VCEHRTESLI QLLHDNLLEQ QAILANFTKD SEYKGSQIQV 300
  301 RSNNFLNQVL DSLRELCQDA IDINPSEMVP DLYHSLSTFP QDNGNNNNNN NNNNNNNNAL 360
  361 LDQFPIQKDT VSLNSYFQFS PRTNHNIQNV TSWQSRFFLN DDQDPGLALL IHDTLDLARK 420
  421 KVDAVLRLDN AMTYSLKIKN EVNNYVVQLI REQIEINKHA ILTHPMNLRS SSIFHSPLPQ 480
  481 IHSQQPEAEN LIYSSSTPLQ VQHDQCASFE APSKSHLEPI PFPVSSIEET PTANDIRHPS 540
  541 PLPRSCSNTV MKLPTPRRKL DSNGLFSDAY LNADIIPNPS IESTISIDRD NNTNSRGSSM 600
  601 KQYGIGEATD SRTSNSERPS SSSSRLGIRS RSITPRQKIE YSHVDNDDRT NEMLSRDKDS 660
  661 LQPQPSVDTT ITSSTQATTT GTKTNSNNST NSVLPKLMTS ISLTPRRGSP SFGNLASHSM 720
  721 QQTNSFKLIH DKSPISSPFT FSKDFLTPEQ HPSNIARTDS INNAMLTSPN MPLSPLLLAT 780
  781 NQTVKSPTPS IKDYDILKPI SKGAYGSVYL ARKKLTGDYF AIKVLRKSDM IAKNQVTNVK 840
  841 SERAIMMVQS DKPYVARLFA SFQNKDNLFL VMEYLPGGDL ATLIKMMGYL PDQWAKQYLT 900
  901 EIVVGVNDMH QNGIIHHDLK PENLLIDNAG HVKLTDFGLS RAGLIRRHKF VPHKSSLSIS 960
  961 STLPIDNPAN NFTMNNNNSN HSQLSTPDSF TSDHKQYNRS KKSSLGQQYE HSEYSSTSNS1020
 1021 HSMTPTPSTN TVVYPSYYRG KDRSHGSSNI DLPASLRRSE SQLSFSLLDI SRSSTPPLAN1080
 1081 PTNSNANNIM RRKSLTENKS FSNDLLSSDA IAATNTNINS NNNISLSPAP SDLALFYPDD1140
 1141 SKQNKKFFGT PDYLAPETIE GKGEDNKQCD WWSVGCIFFE LLLGYPPFHA ETPDAVFKKI1200
 1201 LSGVIQWPEF KNEEEEREFL TPEAKDLIEK LLVVDPAKRL GAKGIQEIKD HPYFKNVDWD1260
 1261 HVYDEEASFV PTIDNPEDTD YFDLRGAELQ DFGDDIENDN ANILFGKHGI NTDVSELSAA1320
 1321 NLSPPLNHKN ILSRKLSMSN TTNRSSNNSN SSVHDFGAHT PVNKLSIASV LESVPQETGY1380
 1381 ITPNGTGTTT TSAKNSPNLK NLSLAIPPHM RDRRSSKLND SQTEFGSFNF RNLSALDKAN1440
 1441 KDAINRLKSE HFSEQPGVHR RTSSASLMGS SSDGSVSTPG SNASNTTSGG KLKIHKPTIS1500
 1501 GSPSTFGTFP KTFLRSDSFS TRSYSPERSI SIDSSTLSRK GSIIGDNQQT TANSSDSPTM1560
 1561 TKFKSPLSPA NTTTVSSYFS RQRVLSKSFS QRTNSSDLSA EESDRLQAIS RVNSLRNRRR1620
 1621 SGRKSSSTSE IGYHMDVLVC EPIPIHRYRV TKDLENLGCT VVSVGAGDEL VSRATSGVSF1680
 1681 DLIMTALKLP KLGAIDIVQL LKQTNGANST TPIVAITNYF QEAATSRVFD DVLEKPVKLD1740
 1741 ELKKLVAKYA LKKSQEDEEH TILSDSDETH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARP7 ARP9 ATG16 CSH1 GRS2 HTL1 MGR1 NFI1 NPL6 PCL9 RIM15 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 URC2 YIL177C
    View Details Ho Y, et al. (2002) BCY1 FET4 PHO85 RIM15 TCP1 TPK1 TPK2 TPK3 VPS13

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RIM15 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..403] deduced N/A No confident structure predictions are available.
    2 View Details [404..785] ORFEUS 11.24 RBP1
    3 View Details [786..980] PSI-BLAST 166.156545 No description for 1lg3A_ was found.
    4 View Details [981..1036]
    [1050..1067]
    [1273..1340]    		 PSI-BLAST 396.0103 cAMP-dependent PK, catalytic subunit
    5 View Details [1037..1049]
    [1068..1272]    		 PSI-BLAST 396.0103 cAMP-dependent PK, catalytic subunit
    6 View Details [1341..1770] deduced N/A No confident structure predictions are available.
    7 View Details [1323..1597] FFAS03 2.08 Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
    8 View Details [1598..1770] FFAS03 4.68 No description for 2ayxA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.0194696248926 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.49476861948897 bayes_pls_golite062009
  • DNA binding
    		•  2.19545186072108 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.12699172468275 bayes_pls_golite062009
  • transcription factor activity
    		•  1.6875078525856 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64278494326255 bayes_pls_golite062009
  • protein binding
    		•  1.60673447924806 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.34369087457971 bayes_pls_golite062009
  • kinase activity
    		•  1.27787411134399 bayes_pls_golite062009
  • transcription factor binding
    		•  1.27388174012263 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.26593567694405 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.865848090169615 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.859295384298456 bayes_pls_golite062009
  • transcription activator activity
    		•  0.76752398979286 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.5476536728695 bayes_pls_golite062009
  • transferase activity
    		•  0.534003294436004 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.3832620238984 bayes_pls_golite062009
  • histone acetyltransferase binding
    		•  0.288153410088245 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.092160501773862 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle