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Protein Overview: URC2

General Information:
Name(s) found: URC2 / YDR520C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 772 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDINSNASVS PRPDGLPMTA GYNSASGKVR NSIRSIINHP EDSARAKERS ETNSPKNNGN  60
   61 KKPRKKRKTF SCDTCRRVKT RCDFEPFIGK CYRCNVLQLD CSLARNKDNE ILNTLREDGL 120
  121 LKKINSINHN LGSFSHLNAD SPNESQSSFE KNGTVNFDNY MIDKRLSSLE EHIKSLHQKM 180
  181 DLIITTAKMS YNSDIKGPGD DIQNVDFSSN KTYDSRLTSG SETIRKTGEY RKENLFLNGF 240
  241 KLKESPLKLL HDIDERLFPS KATSKAAKLA GQQRPYAVAR VNFLHFYENN QELCHKLAKE 300
  301 FLVRSHFWII PGGRKEIDVE YAHSHLFITS VFTIIAMSFA DNDKYAAEQE ILYPLVERLL 360
  361 TNTLTMFEKL TAFDIEAILY CCMFHISRKA KRYRQLKFNS LVLSNFALNS LLHVIDFYQI 420
  421 KDRVLVKEVY NPEDLYHLRI LNSLTACYLE YSISYGDIRE QDDMLKEFNK LVAKFPQANF 480
  481 GDDIKISEIN LGDIVNGIFI NLKNYFAQCL DDFNNDRYGG NADTFIFVFP ELNYWLKNWE 540
  541 ELLAKDGAGV LLFTFDFYHI MICRTFITEF SSTLKSNQRF LKLILNTMKE HSFSLLNGFL 600
  601 RLPPTLIRGA PIFTCHQLVY ACLTLCDYLY WFDSSERQRV LSLCTKVYWH LSTIGEKMNE 660
  661 ATDNVGKIIK SIIDTSKTRI NFGSLSKENS DNDKMSTNAN NYTGAGNLHA AKPATSPTNV 720
  721 GTLHENLSSS HFMIPDVDQF NSFEDFFQDF FDSLKPNSQK MFTSDKKTEQ TT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARP7 ARP9 ATG16 CSH1 GRS2 HTL1 MGR1 NFI1 NPL6 PCL9 RIM15 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 URC2 YIL177C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data URC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 12.09691 Hap1 (Cyp1); HAP1
    2 View Details [152..342] deduced N/A No confident structure predictions are available.
    3 View Details [343..533]
    [574..681]    		 ORFEUS 7.33 Hemolysin E (HlyE, ClyA, SheA)
    4 View Details [534..573] ORFEUS 7.33 Hemolysin E (HlyE, ClyA, SheA)
    5 View Details [682..772] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  2.84103204571231 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.75876859131052 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74384406575369 bayes_pls_golite062009
  • binding
    		•  2.17040631935413 bayes_pls_golite062009
  • transcription factor activity
    		•  1.58356557490942 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.04526784942456 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.96356124803142 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.81674649742763 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle