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View Structure Prediction Details

Protein: URC2
Organism: Saccharomyces cerevisiae
Length: 772 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URC2.

Description E-value Query
Range		 Subject
Range
gi|151942481 - gi|151942481|gb|EDN60837.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|190404562 - gi|190404562|gb|EDV07829.1| hypothetical protein SCRG_00023 [Saccharomyces cerevisiae RM11-1a]
URC2 - Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a scree...
URC2_YEAST - Uracil catabolism protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URC2 PE=1 SV...
 0.0 [1..772] [1..772]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-48 [42..350] [9..306]
THI1_SCHPO - Thiamine repressible genes regulatory protein thi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
thi1 - transcription factor Thi1
 5.0E-47 [42..350] [9..306]
SPAC3C7.04 - transcription factor
YF54_SCHPO - Uncharacterized transcriptional regulatory protein C3C7.04 OS=Schizosaccharomyces pombe (strain 972 ...
 1.0E-39 [38..346] [6..318]

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Predicted Domain #1
Region A:
Residues: [1-151] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDINSNASVS PRPDGLPMTA GYNSASGKVR NSIRSIINHP EDSARAKERS ETNSPKNNGN  60
   61 KKPRKKRKTF SCDTCRRVKT RCDFEPFIGK CYRCNVLQLD CSLARNKDNE ILNTLREDGL 120
  121 LKKINSINHN LGSFSHLNAD SPNESQSSFE K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 1hwtC_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 2.84103204571231 bayes_pls_golite062009
transcription regulator activity 2.75876859131052 bayes_pls_golite062009
nucleic acid binding 2.74384406575369 bayes_pls_golite062009
binding 2.17040631935413 bayes_pls_golite062009
transcription factor activity 1.58356557490942 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.04526784942456 bayes_pls_golite062009
sequence-specific DNA binding 0.96356124803142 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.81674649742763 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [152-342] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGTVNFDNYM IDKRLSSLEE HIKSLHQKMD LIITTAKMSY NSDIKGPGDD IQNVDFSSNK  60
   61 TYDSRLTSGS ETIRKTGEYR KENLFLNGFK LKESPLKLLH DIDERLFPSK ATSKAAKLAG 120
  121 QQRPYAVARV NFLHFYENNQ ELCHKLAKEF LVRSHFWIIP GGRKEIDVEY AHSHLFITSV 180
  181 FTIIAMSFAD N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [343-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKYAAEQEIL YPLVERLLTN TLTMFEKLTA FDIEAILYCC MFHISRKAKR YRQLKFNSLV  60
   61 LSNFALNSLL HVIDFYQIKD RVLVKEVYNP EDLYHLRILN SLTACYLEYS ISYGDIREQD 120
  121 DMLKEFNKLV AKFPQANFGD DIKISEINLG DIVNGIFINL KNYFAQCLDD FNNDRYGGNA 180
  181 DTFIFVFPEL N

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [574-681] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKSNQRFLKL ILNTMKEHSF SLLNGFLRLP PTLIRGAPIF TCHQLVYACL TLCDYLYWFD  60
   61 SSERQRVLSL CTKVYWHLST IGEKMNEATD NVGKIIKSII DTSKTRIN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.33
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [534-573] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YWLKNWEELL AKDGAGVLLF TFDFYHIMIC RTFITEFSST

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.33
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [682-772] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGSLSKENSD NDKMSTNANN YTGAGNLHAA KPATSPTNVG TLHENLSSSH FMIPDVDQFN  60
   61 SFEDFFQDFF DSLKPNSQKM FTSDKKTEQT T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.290 0.857 nucleus a.4.5 "Winged helix" DNA-binding domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle