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Protein Overview: STH1

General Information:
Name(s) found: STH1 / YIL126W [SGD]
Description(s) found:
Found 25 descriptions.
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  • ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1359 amino acids

    Gene Ontology:
    Cellular Component: RSC complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    Biological Process: cytoskeleton organization [IMPLink to PubMed article]
    ATP-dependent chromatin remodeling [IDALink to PubMed articleLink to PubMed article]
    chromosome segregation [IGILink to PubMed article]
    chromatin remodeling at centromere [IMPLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    double-strand break repair [IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    DNA-dependent ATPase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQEQSELMS TVMNNTPTTV AALAAVAAAS ETNGKLGSEE QPEITIPKPR SSAQLEQLLY  60
   61 RYRAIQNHPK ENKLEIKAIE DTFRNISRDQ DIYETKLDTL RKSIDKGFQY DEDLLNKHLV 120
  121 ALQLLEKDTD VPDYFLDLPD TKNDNTTAIE VDYSEKKPIK ISADFNAKAK SLGLESKFSN 180
  181 ATKTALGDPD TEIRISARIS NRINELERLP ANLGTYSLDD CLEFITKDDL SSRMDTFKIK 240
  241 ALVELKSLKL LTKQKSIRQK LINNVASQAH HNIPYLRDSP FTAAAQRSVQ IRSKVIVPQT 300
  301 VRLAEELERQ QLLEKRKKER NLHLQKINSI IDFIKERQSE QWSRQERCFQ FGRLGASLHN 360
  361 QMEKDEQKRI ERTAKQRLAA LKSNDEEAYL KLLDQTKDTR ITQLLRQTNS FLDSLSEAVR 420
  421 AQQNEAKILH GEEVQPITDE EREKTDYYEV AHRIKEKIDK QPSILVGGTL KEYQLRGLEW 480
  481 MVSLYNNHLN GILADEMGLG KTIQSISLIT YLYEVKKDIG PFLVIVPLST ITNWTLEFEK 540
  541 WAPSLNTIIY KGTPNQRHSL QHQIRVGNFD VLLTTYEYII KDKSLLSKHD WAHMIIDEGH 600
  601 RMKNAQSKLS FTISHYYRTR NRLILTGTPL QNNLPELWAL LNFVLPKIFN SAKTFEDWFN 660
  661 TPFANTGTQE KLELTEEETL LIIRRLHKVL RPFLLRRLKK EVEKDLPDKV EKVIKCKLSG 720
  721 LQQQLYQQML KHNALFVGAG TEGATKGGIK GLNNKIMQLR KICNHPFVFD EVEGVVNPSR 780
  781 GNSDLLFRVA GKFELLDRVL PKFKASGHRV LMFFQMTQVM DIMEDFLRMK DLKYMRLDGS 840
  841 TKTEERTEML NAFNAPDSDY FCFLLSTRAG GLGLNLQTAD TVIIFDTDWN PHQDLQAQDR 900
  901 AHRIGQKNEV RILRLITTDS VEEVILERAM QKLDIDGKVI QAGKFDNKST AEEQEAFLRR 960
  961 LIESETNRDD DDKAELDDDE LNDTLARSAD EKILFDKIDK ERMNQERADA KAQGLRVPPP1020
 1021 RLIQLDELPK VFREDIEEHF KKEDSEPLGR IRQKKRVYYD DGLTEEQFLE AVEDDNMSLE1080
 1081 DAIKKRREAR ERRRLRQNGT KENEIETLEN TPEASETSLI ENNSFTAAVD EETNADKETT1140
 1141 ASRSKRRSSR KKRTISIVTA EDKENTQEES TSQENGGAKV EEEVKSSSVE IINGSESKKK1200
 1201 KPKLTVKIKL NKTTVLENND GKRAEEKPES KSPAKKTAAK KTKTKSKSLG IFPTVEKLVE1260
 1261 EMREQLDEVD SHPRTSIFEK LPSKRDYPDY FKVIEKPMAI DIILKNCKNG TYKTLEEVRQ1320
 1321 ALQTMFENAR FYNEEGSWVY VDADKLNEFT DEWFKEHSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP7 ARP9 HTB1 HTL1 ISW1 ISW2 ITC1 MOT1 NFI1 NPL6 RSC1 RSC2 RSC3 RSC30 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 VPS1
    View Details (MIPS) Mewes HW, et al. (2004) ARP7 ARP9 RSC1 RSC2 RSC4 RSC6 RSC8 SAS5 SFH1 STH1
    View Details Krogan NJ, et al. (2006) ARP7 ARP9 ATG16 CSH1 GRS2 HTL1 MGR1 NFI1 NPL6 PCL9 RIM15 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 URC2 YIL177C
    View Details Gavin AC, et al. (2006) ARP7 NPL6 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 SFH1 STH1
    View Details Gavin AC, et al. (2002) ADE5,7 DPB2 DPB4 HHF1, HHF2 IOC3 ISW1 ISW2 ITC1 KAP114 MOT1 NAP1 NPL6 POL2 PUF6 REB1 RET1 RFA1 RFX1 RNR2 RPA135 RPC34 RPC40 RPC82 RPO31 RSC2 RSC3 RSC58 RSC8 RVB2 SFH1 STH1 STO1 TAF1 TFC7 TOP1 VPS1 YBR090C-A, NHP6B
    View Details Ho Y, et al. (2002) DMA2 GDE1 PHO84 STH1
    View Details Qiu et al. (2008) ARP7 ARP9 HTL1 RSC4 RSC58 RSC6 RSC8 SAS5 SFH1 SNF5 STH1 TAF14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] deduced N/A No confident structure predictions are available.
    2 View Details [234..277]
    [367..431]    		 PSI-BLAST 4.0 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    3 View Details [278..366]
    [432..649]    		 PSI-BLAST 4.0 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    4 View Details [650..707] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [708..919] PSI-BLAST 3.0 Putative DEAD box RNA helicase
    6 View Details [920..1146] MSA 3.390994 View MSA. No confident structure predictions are available.
    7 View Details [1147..1227] deduced N/A No confident structure predictions are available.
    8 View Details [1228..1359] PSI-BLAST 72.522879 GCN5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.41724497205118 bayes_pls_golite062009
  • protein binding
    		•  1.23494952402126 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.4348680404207 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • motor activity
    		•  1.19366988459523 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.170087579765 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.11383295816593 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.07968294254548 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • actin binding
    		•  0.0206144204131673 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.46

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle