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Protein Overview: HTB1

General Information:
Name(s) found: HTB1 / YDR224C [SGD]
Description(s) found:
Found 39 descriptions.
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  • Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 131 amino acids

    Gene Ontology:
    Cellular Component: nuclear nucleosome [IDALink to PubMed article]
    Biological Process: chromatin assembly or disassembly [IDALink to PubMed articleLink to PubMed article]
    postreplication repair [IGILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKAEKKPA SKAPAEKKPA AKKTSTSTDG KKRSKARKET YSSYIYKVLK QTHPDTGISQ  60
   61 KSMSILNSFV NDIFERIATE ASKLAAYNKK STISAREIQT AVRLILPGEL AKHAVSEGTR 120
  121 AVTKYSSSTQ A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HHF1, HHF2 HTA1 HTA2 HTB1 KAP114 MOT1 RSC8 STH1
    View Details (MIPS) Mewes HW, et al. (2004) HHF1, HHF2 HHT1, HHT2 HTA1 HTA2 HTB1 HTB2
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Ho Y, et al. (2002) ADH2 AFG2 AHA1 AHP1 AIM21 ALB1 AMS1 ARF1 ARP2 ARX1 BIK1 BRX1 BUD20 BUD3 CBF5 CBP2 CCT2 CCT3 CCT6 CDC28 CDC33 CEG1 CIC1 CIN8 CKA1 CKA2 CKB1 CKB2 CLU1 COF1 CPR1 CYS4 DBP7 DRS1 DUN1 EDE1 EHD3 ENP2 ERB1 ESF1 ESF2 FKH1 FYV4 FYV8 GAC1 GCD11 GCD2 GCD7 GCN3 GND1 GPG1 GPI15 HEF3 HHF1, HHF2 HHT1, HHT2 HIR1 HIR2 HMO1 HTA1 HTA2 HTB1 HTB2 HYP2 IMD3 INO4 KAP114 KAP95 KNS1 KRE33 KRI1 KRR1 LAA1 LAP4 LHP1 LHS1 LSM2 MAM33 MBP1 MDH1 MGE1 MGM101 MGT1 MKT1 MNP1 MPH1 MRPS16 MSH3 MSS116 NAN1 NAP1 NET1 NIP7 NMD3 NOB1 NOG1 NOP1 NOP12 NOP13 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA2 NUG1 OYE2 PMA1 POB3 POL5 PRP43 PSE1 PSH1 PUF6 PWP1 RET1 RFA2 RIP1 RIX1 RLP24 RNQ1 RNR1 RNR3 RPC82 RPF2 RPN12 RPN9 RPO31 RRP1 RRP12 RSM24 RSM25 RVB1 SEC2 SEC27 SIN3 SOF1 SPT16 SSD1 STE12 SUI2 SUI3 SYP1 TEC1 TEF4 TIF1, TIF2 TIF4631 TIF6 TMA19 TSR1 UBP12 UBR1 URE2 UTP10 UTP13 UTP20 UTP22 UTP4 UTP7 VMA4 YBL044W YCR087W YDR102C YFL006W YGR017W YHR033W YMR144W YNL134C YRA1
    View Details Qiu et al. (2008) HHF1, HHF2 HHT1, HHT2 HTA1 HTA2 HTB1 HTB2 PCC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HTB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] PSI-BLAST 426.124002 Histone H2B


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle