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Protein Overview: FKH1

General Information:
Name(s) found: FKH1 / YIL131C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 484 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pseudohyphal growth [IGILink to PubMed articleLink to PubMed article]
    negative regulation of cell cycle [IMPLink to PubMed article]
    positive regulation of cell cycle [IGILink to PubMed articleLink to PubMed articleLink to PubMed article]
    regulation of transcription involved in G2/M-phase of mitotic cell cycle [IGILink to PubMed articleLink to PubMed articleLink to PubMed article]
    termination of RNA polymerase II transcription [IGILink to PubMed article][IMPLink to PubMed article]
    donor selection [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    chromatin silencing at silent mating-type cassette [IGILink to PubMed article][IMPLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [IGILink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]
    centromeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL SIAREVNAYA  60
   61 KIAGCDWTYY VQKLEVTIGR NTDSLNLNAV PGTVVKKNID IDLGPAKIVS RKHAAIRFNL 120
  121 ESGSWELQIF GRNGAKVNFR RIPTGPDSPP TVLQSGCIID IGGVQMIFIL PEQETIISDY 180
  181 CLNHLMPKLL STYGTNGNNN PLLRNIIEGS TYLREQRLQE EARLQQLDHL HTPLSSSSDV 240
  241 NPIGDPHGDT IMMEEDEEDE NYTRGGIRPN TYTSSSNNAV TNGNVPHIEN PSDLSLDENR 300
  301 YIKPPQSYAS MITQAILSTP EGSISLADIY KFISDNYAFY RFSQMAWQNS VRHNLSLNKA 360
  361 FEKVPKRAGQ QGKGMNWKIS DEVRRDFLNK WNAGKLSKIR RGASVTRQLQ LHMSKFGEIP 420
  421 APESSSIDPR GIKAQKVKKS LQATSSILGE SAPQLQRTQL TGQISTTTSM DVTTNANVNN 480
  481 SSLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CDC28 CEG1 CKA1 CKA2 CKB1 CKB2 FKH1 FYV8 GCD2 GCD7 GCN3 HHF1, HHF2 HTB1 MBP1 MGM101 MPH1 NET1 NOP1 RRP1 SEC2 SIN3 SUI2 SUI3 UBP12 URE2 YGR017W YMR144W
    View Details Qiu et al. (2008) FKH1 FKH2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FKH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..189] Pfam 20.958607 FHA domain No confident structure predictions are available.
    3 View Details [190..294] MSA 3.207997 View MSA. No confident structure predictions are available.
    4 View Details [295..414] PSI-BLAST 229.529817 Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
    5 View Details [415..484] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.49130250684713 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.38780975952028 bayes_pls_golite062009
  • protein binding
    		•  3.25414571587883 bayes_pls_golite062009
  • DNA binding
    		•  3.17754626214699 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.1171915055278 bayes_pls_golite062009
  • transcription activator activity
    		•  2.78535001965943 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.68762321363292 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.41431149922235 bayes_pls_golite062009
  • transcription factor activity
    		•  2.00503872581265 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.70605033973639 bayes_pls_golite062009
  • chromatin binding
    		•  1.24734533820287 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  1.22691767140341 bayes_pls_golite062009
  • promoter binding
    		•  1.19827477319554 bayes_pls_golite062009
  • transcription factor binding
    		•  0.840886266060694 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  0.829235284155381 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.799061296723533 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.609339192036706 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  0.557735630718468 bayes_pls_golite062009
  • SMAD binding
    		•  0.421497570548243 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.196567610974905 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.195556172286344 bayes_pls_golite062009
  • R-SMAD binding
    		•  0.18488905369604 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.801431089034975 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription termination factor activity
    		•  0.471608452842719 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.379762425417023 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle