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Protein Overview: FKH2

General Information:
Name(s) found: FKH2 / YNL068C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 862 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pseudohyphal growth [IGILink to PubMed articleLink to PubMed article]
    positive regulation of cell cycle [IGILink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    regulation of transcription involved in G2/M-phase of mitotic cell cycle [IGILink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article][IPILink to PubMed article]
    specific RNA polymerase II transcription factor activity [IDALink to PubMed article][IGILink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSNFNEMN ELNMTQTNYG STKYTAQHHQ GVINAIISSL TAPDQPTTVS LQYSNDKNMA  60
   61 TEIQAYAKLS GPNWTYYVKD LEVSIGRNTD PLNSALQENS DGVKNSYRVN IDLGPAKVVS 120
  121 RKHAIIKYNM NIGGWELHIL GRNGAKVNFQ RTHNGPNNPP IRLSSGTLLD IGGTQMMFIL 180
  181 PDSDPVVAPI CIEHLMPNLI NMFGLEGNNN PLLRDIIKQS NYAKQRQLTS NQQIKGFKLY 240
  241 GSGGNAPFGS GANLGPSEQG IFNNNNNSKN KNGYFTSINP NYTASTTTSN TINPQAASPQ 300
  301 GPPNTIIAAN FVDSYKSSNA YPQALDFTSD LSHDENRNVK PPHSYATMIT QAILSSPEGV 360
  361 ISLADIYKYI SSNYAYYRFA KSGWQNSIRH NLSLNKAFEK VPRRPNEPGK GMKWRISESY 420
  421 QQEFLNKWNT GKVGKIRRGS SVARQLQLHM AKFNSLPMEM DYRLSLNMAQ PPKRQLQSHN 480
  481 VLEPSNNNII EGFVQHVPSK GNLPASQQSQ PPVSHQNQSQ QPPPQEQRQE IQFTFADTQN 540
  541 RNIALARPIK TPQLQAPNSN ANLNQNNMKE YKESLHPPAI SISQMNRQSP NNALVSFTNA 600
  601 CANSKIINNI SDSADKSTNN NGGTKMNLPA ISTSSLDENG NLEPTTTTSS GNSNSVPQTG 660
  661 TTTSSLAANS LRLSQPYDTL LRSPTKAFHI TAMEAYTPER GSANRARSPL HSNSNNTNNN 720
  721 GANNSNLQTS GMENKQTGLV LDSNVLKSME SNNDNRRLTP STSKSQNVKS SPGVWNLLQF 780
  781 SSTNNTPAAD SGGNKRGFSI NPDIKAKENE NATSEKDSDS NSNDLETKDI NSSPLKNQGG 840
  841 STANAKELIL DTDGAKISII NN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACE2 FKH2 RTC4 SWP1 YIL108W
    View Details Ho Y, et al. (2002) ADH2 FKH2 HTB2 INO80 SIN3
    View Details Qiu et al. (2008) ADA2 FKH1 FKH2 LCB3 RKI1 TOS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FKH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] ab initio 12.16 No description for 1g3gA was found.
    2 View Details [215..337] deduced N/A No confident structure predictions are available.
    3 View Details [338..430] PSI-BLAST 217.9897 Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
    4 View Details [431..862] ab initio 11.22 No description for 1i3qA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle