YRC Public Data Repository - Protein Structure Prediction

Protein:	FKH1
Organism:	Saccharomyces cerevisiae
Length:	484 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FKH1.

Description	E-value	Query Range	Subject Range
FKH1_YEAST - Fork head protein homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FKH1 PE=1 SV... FKH1 - Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negati...	0.0	[1..484]	[1..484]
fhl1 - fork head transcription factor Fhl1 FHL1_SCHPO - Fork head transcription factor 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fhl1 PE=3...	3.0E-64	[39..446]	[2..431]
FOXK1_MOUSE, FXK... - (P42128) Forkhead box protein K1 (Myocyte nuclear factor) (MNF), (P42128) Forkhead box protein K1 (M...	3.0E-59	[58..481]	[89..461]
FOXA2_ORYLA - Hepatocyte nuclear factor 3-beta OS=Oryzias latipes GN=foxa2 PE=2 SV=1	3.0E-52	[171..479]	[23..339]
gi\|12657603 - gi\|12657603\|dbj\|BAB21570.1\| transcription factor Foxa2 [Colisa lalia]	4.0E-51	[177..479]	[21..339]
gi\|18378127 - gi\|18378127\|gb\|AAL68498.1\|AF251499_1 hepatocyte nuclear factor 3-beta [Oreochromis mossambicus]	1.0E-50	[171..479]	[23..337]
ENSPTRT00000042968 - null gi\|12043718 - gi\|12043718\|gb\|AAG47634.1\| FOXP1 [Homo sapiens]	5.0E-48	[144..478]	[90..445]

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Predicted Domain #1

Region A:
Residues: [1-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL SIAREVNAYA  60
   61 KIAGCDWTYY VQKL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	3.49130250684713	bayes_pls_golite062009
transcription regulator activity	3.38780975952028	bayes_pls_golite062009
protein binding	3.25414571587883	bayes_pls_golite062009
DNA binding	3.17754626214699	bayes_pls_golite062009
nucleic acid binding	3.1171915055278	bayes_pls_golite062009
transcription activator activity	2.78535001965943	bayes_pls_golite062009
sequence-specific DNA binding	2.68762321363292	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.41431149922235	bayes_pls_golite062009
transcription factor activity	2.00503872581265	bayes_pls_golite062009
transcription repressor activity	1.70605033973639	bayes_pls_golite062009
chromatin binding	1.24734533820287	bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity	1.22691767140341	bayes_pls_golite062009
promoter binding	1.19827477319554	bayes_pls_golite062009
transcription factor binding	0.840886266060694	bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	0.829235284155381	bayes_pls_golite062009
structure-specific DNA binding	0.799061296723533	bayes_pls_golite062009
double-stranded DNA binding	0.609339192036706	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity	0.557735630718468	bayes_pls_golite062009
SMAD binding	0.421497570548243	bayes_pls_golite062009
receptor signaling protein activity	0.196567610974905	bayes_pls_golite062009
protein dimerization activity	0.195556172286344	bayes_pls_golite062009
R-SMAD binding	0.18488905369604	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [75-189]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVTIGRNTDS LNLNAVPGTV VKKNIDIDLG PAKIVSRKHA AIRFNLESGS WELQIFGRNG  60
   61 AKVNFRRIPT GPDSPPTVLQ SGCIIDIGGV QMIFILPEQE TIISDYCLNH LMPKL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	20.958607
Match:	PF00498
Description:	FHA domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [190-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSTYGTNGNN NPLLRNIIEG STYLREQRLQ EEARLQQLDH LHTPLSSSSD VNPIGDPHGD  60
   61 TIMMEEDEED ENYTRGGIRP NTYTSSSNNA VTNGNVPHIE NPSDL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	5.08959163553491	bayes_pls_golite062009
nucleic acid binding	4.99681957904233	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
transcription repressor activity	3.85678231380989	bayes_pls_golite062009
transcription activator activity	3.70589483230587	bayes_pls_golite062009
sequence-specific DNA binding	3.58179858678904	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.60738445921725	bayes_pls_golite062009
protein binding	1.80415286835431	bayes_pls_golite062009
specific transcriptional repressor activity	0.96257232341735	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
transcription elongation regulator activity	0.801431089034975	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.66743181561551	bayes_pls_golite062009
transcription termination factor activity	0.471608452842719	bayes_pls_golite062009
structure-specific DNA binding	0.379762425417023	bayes_pls_golite062009
transcription corepressor activity	0.322180400748724	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.23177057841536	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [295-414]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDENRYIKP PQSYASMITQ AILSTPEGSI SLADIYKFIS DNYAFYRFSQ MAWQNSVRHN  60
   61 LSLNKAFEKV PKRAGQQGKG MNWKISDEVR RDFLNKWNAG KLSKIRRGAS VTRQLQLHMS 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	229.529817
Match:	1d5vA_
Description:	Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [415-484]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFGEIPAPES SSIDPRGIKA QKVKKSLQAT SSILGESAPQ LQRTQLTGQI STTTSMDVTT  60
   61 NANVNNSSLS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: