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Protein Overview: fhl1

General Information:
Name(s) found: fhl1 / SPAC1142.08 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • fork head transcription factor Fhl1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 743 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [TASLink to PubMed article]
    gene-specific transcription from RNA polymerase II promoter [RCALink to PubMed article]
    Molecular Function: transcription factor activity [TASLink to PubMed article]
    specific RNA polymerase II transcription factor activity [RCALink to PubMed article]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVAEIKNAT QQPSSTNRVQ AYAKLEFEKF SFFVQTLQVT MGRKASNSSD CDVHLGDTKA  60
   61 ISRQHAKIFY SFPNQRFEIS VMGKNGAFVD GEFVERGKSV PLRSGTRVQI GQISFSFLLP 120
  121 EGSEEDGHLK ETGITPLSLQ QGKIAYSDEF GGKPTGSFHT VTSNQEKDLL FSHIKHESDL 180
  181 PLGLSPADTN ISNATSIIEH PDAANAHTLA SLNQPPKHLT VSPSSIQRLS PQPYVRPTSD 240
  241 ERPIETDSSV SAPKVANHDE ELKQGKSTSP SDTVLHPDLN GSPDTGDATQ KPNLSYANLI 300
  301 ARTLIANPNK KMTLGDICEW IANNWSYYRH QPPAWHNSIR HNLSLNKAFI RIPRRQNEPG 360
  361 KGSFWMLDPS YIDQFEGNFF RRTKKPTPSA TPAAHPDTAR ENELAAIQTK GISAGKTEQL 420
  421 NPQKETSRSK THTSRGENVE DRPQSLLQNG IQPIIMRDGK LALNPEFFKN ANGEQQAPNE 480
  481 QAVQAISLLQ QHINKQLGPA AANNPEQATA IANALAVALA QKLQKQQTQM QGPQQVQQQA 540
  541 KRRKAYTSQQ LNPAPTAMPH PNITSPSPSI SVTQRPAVNV GPPPYVRPSA PSKLPDTRQS 600
  601 IGDPLPPGAM ANVSAGPSSV RSSSYNSTAS ESKSEITSHQ NLHTIPINKP FTSDRPLYSS 660
  661 PNDTLERVET GNQGQRMNSI GNASSFSKRD IMENENGSFD TNAKNGNNVD DSSSVRGMNL 720
  721 PSNSSDALRG VKRPLDETSS SYT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 13.39794 Cell cycle checkpoint protein Chfr
    2 View Details [156..276] deduced N/A No confident structure predictions are available.
    3 View Details [277..383] PSI-BLAST 31.045757 Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
    4 View Details [384..482] deduced N/A No confident structure predictions are available.
    5 View Details [483..587] MSA 3.303997 View MSA. No confident structure predictions are available.
    6 View Details [588..743] MSA 4.229988 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49687772656017 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • DNA binding
    		•  3.30334070294767 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.21526555447097 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  3.11955149440894 bayes_pls_golite062009
  • transcription activator activity
    		•  2.94935902482394 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.89799244272809 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.88406197124131 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  2.71069110696713 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.61166537801555 bayes_pls_golite062009
  • R-SMAD binding
    		•  2.6025306793153 bayes_pls_golite062009
  • promoter binding
    		•  2.30493918456602 bayes_pls_golite062009
  • transcription factor activity
    		•  2.08449567315174 bayes_pls_golite062009
  • co-SMAD binding
    		•  1.88371912855333 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.74929788315626 bayes_pls_golite062009
  • SMAD binding
    		•  1.58868248655216 bayes_pls_golite062009
  • chromatin binding
    		•  1.44267609273288 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95553719139833 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.578078880190858 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • histone binding
    		•  0.27452633104793 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.242323296067 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.163947452198109 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.161373857796846 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.161373857796846 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.15013949452504 bayes_pls_golite062009
  • receptor binding
    		•  0.0581553668794451 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle