| Protein: | FKH1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 484 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FKH1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..484] | [1..484] |
|
|
3.0E-64 | [39..446] | [2..431] |
|
|
3.0E-59 | [58..481] | [89..461] |
|
|
3.0E-52 | [171..479] | [23..339] |
|
|
4.0E-51 | [177..479] | [21..339] |
|
|
1.0E-50 | [171..479] | [23..337] |
|
|
5.0E-48 | [144..478] | [90..445] |
|
Region A: Residues: [1-74] |
1 11 21 31 41 51
| | | | | |
1 MSVTSREQKF SGKYSSYTAQ DRQGLVNAVT CVLSSSSDPV AVSSDYSNSL SIAREVNAYA 60
61 KIAGCDWTYY VQKL
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.584 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.767 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.519 | a.13.1 | alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 |
| View | Download | 0.560 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.492 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.449 | d.43.1 | Elongation factor Ts (EF-Ts), dimerisation domain |
| View | Download | 0.429 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.423 | a.144.2 | Ribosomal protein L20 |
| View | Download | 0.414 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.389 | d.58.17 | Metal-binding domain |
| View | Download | 0.360 | a.23.4 | Mitochondrial import receptor subunit Tom20 |
| View | Download | 0.357 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.357 | d.68.6 | DNA-binding protein Sso10b (AlbA) |
| View | Download | 0.352 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.339 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.321 | a.4.1 | Homeodomain-like |
| View | Download | 0.317 | a.118.1 | ARM repeat |
| View | Download | 0.316 | a.60.5 | Barrier-to-autointegration factor, BAF |
| View | Download | 0.308 | a.64.2 | Bacteriocin AS-48 |
| View | Download | 0.303 | a.23.5 | Hemolysin expression modulating protein HHA |
| View | Download | 0.297 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.282 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.272 | a.4.1 | Homeodomain-like |
| View | Download | 0.265 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.264 | d.95.2 | Homing endonucleases |
| View | Download | 0.264 | a.28.2 | Colicin E immunity proteins |
| View | Download | 0.263 | a.30.2 | Homodimeric domain of signal transducing histidine kinase |
| View | Download | 0.252 | a.3.1 | Cytochrome c |
| View | Download | 0.230 | a.4.13 | Sigma3 and sigma4 domains of RNA polymerase sigma factors |
| View | Download | 0.229 | c.55.4 | Translational machinery components |
| View | Download | 0.228 | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.223 | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.219 | a.118.13 | Arp2/3 complex 16 kDa subunit ARPC5 |
| View | Download | 0.209 | d.169.1 | C-type lectin-like |
| View | Download | 0.207 | a.1.1 | Globin-like |
| View | Download | 0.203 | a.77.1 | DEATH domain |
| Term | Confidence | Notes |
| binding | 3.49130250684713 | bayes_pls_golite062009 |
| transcription regulator activity | 3.38780975952028 | bayes_pls_golite062009 |
| protein binding | 3.25414571587883 | bayes_pls_golite062009 |
| DNA binding | 3.17754626214699 | bayes_pls_golite062009 |
| nucleic acid binding | 3.1171915055278 | bayes_pls_golite062009 |
| transcription activator activity | 2.78535001965943 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.68762321363292 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.41431149922235 | bayes_pls_golite062009 |
| transcription factor activity | 2.00503872581265 | bayes_pls_golite062009 |
| transcription repressor activity | 1.70605033973639 | bayes_pls_golite062009 |
| chromatin binding | 1.24734533820287 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, cytoplasmic mediator activity | 1.22691767140341 | bayes_pls_golite062009 |
| promoter binding | 1.19827477319554 | bayes_pls_golite062009 |
| transcription factor binding | 0.840886266060694 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | 0.829235284155381 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.799061296723533 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.609339192036706 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase signaling protein activity | 0.557735630718468 | bayes_pls_golite062009 |
| SMAD binding | 0.421497570548243 | bayes_pls_golite062009 |
| receptor signaling protein activity | 0.196567610974905 | bayes_pls_golite062009 |
| protein dimerization activity | 0.195556172286344 | bayes_pls_golite062009 |
| R-SMAD binding | 0.18488905369604 | bayes_pls_golite062009 |
|
Region A: Residues: [75-189] |
1 11 21 31 41 51
| | | | | |
1 EVTIGRNTDS LNLNAVPGTV VKKNIDIDLG PAKIVSRKHA AIRFNLESGS WELQIFGRNG 60
61 AKVNFRRIPT GPDSPPTVLQ SGCIIDIGGV QMIFILPEQE TIISDYCLNH LMPKL
|
| Detection Method: | |
| Confidence: | 20.958607 |
| Match: | PF00498 |
| Description: | FHA domain |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.684 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.606 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.555 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.448 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.423 | N/A | N/A | a.56.1 | CO dehydrogenase ISP C-domain like |
|
Region A: Residues: [190-294] |
1 11 21 31 41 51
| | | | | |
1 LSTYGTNGNN NPLLRNIIEG STYLREQRLQ EEARLQQLDH LHTPLSSSSD VNPIGDPHGD 60
61 TIMMEEDEED ENYTRGGIRP NTYTSSSNNA VTNGNVPHIE NPSDL
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.421 | 0.436 | chromatin silencing at silent mating-type cassette | a.1.1 | Globin-like |
| View | Download | 0.684 | 0.100 | chromatin silencing at silent mating-type cassette | a.74.1 | Cyclin-like |
| View | Download | 0.423 | 0.037 | chromatin silencing at silent mating-type cassette | a.56.1 | CO dehydrogenase ISP C-domain like |
| View | Download | 0.410 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.406 | N/A | N/A | a.11.2 | Second domain of FERM |
| View | Download | 0.373 | N/A | N/A | c.78.2 | Aspartate/glutamate racemase |
| View | Download | 0.354 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.340 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.337 | N/A | N/A | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.335 | N/A | N/A | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.324 | N/A | N/A | a.181.1 | Antibiotic binding domain of TipA-like multidrug resistance regulators |
| View | Download | 0.312 | N/A | N/A | a.24.15 | FAD-dependent thiol oxidase |
| View | Download | 0.300 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.293 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.292 | N/A | N/A | c.97.1 | Cytidine deaminase-like |
| View | Download | 0.285 | N/A | N/A | a.4.1 | Homeodomain-like |
| View | Download | 0.278 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.277 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.271 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.252 | N/A | N/A | a.24.4 | Hemerythrin |
| View | Download | 0.249 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.239 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.233 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.227 | N/A | N/A | d.94.1 | HPr-like |
| View | Download | 0.227 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.218 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.218 | N/A | N/A | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.215 | N/A | N/A | a.91.1 | Regulator of G-protein signalling, RGS |
| View | Download | 0.214 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.209 | N/A | N/A | a.2.7 | tRNA-binding arm |
| Term | Confidence | Notes |
| transcription regulator activity | 5.55329976718261 | bayes_pls_golite062009 |
| DNA binding | 5.08959163553491 | bayes_pls_golite062009 |
| nucleic acid binding | 4.99681957904233 | bayes_pls_golite062009 |
| transcription factor activity | 4.33152142980289 | bayes_pls_golite062009 |
| transcription repressor activity | 3.85678231380989 | bayes_pls_golite062009 |
| transcription activator activity | 3.70589483230587 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 3.58179858678904 | bayes_pls_golite062009 |
| binding | 3.52874320222492 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.60738445921725 | bayes_pls_golite062009 |
| protein binding | 1.80415286835431 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.96257232341735 | bayes_pls_golite062009 |
| transcription factor binding | 0.85714789329232 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 0.801431089034975 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 0.66743181561551 | bayes_pls_golite062009 |
| transcription termination factor activity | 0.471608452842719 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.379762425417023 | bayes_pls_golite062009 |
| transcription corepressor activity | 0.322180400748724 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.23177057841536 | bayes_pls_golite062009 |
|
Region A: Residues: [295-414] |
1 11 21 31 41 51
| | | | | |
1 SLDENRYIKP PQSYASMITQ AILSTPEGSI SLADIYKFIS DNYAFYRFSQ MAWQNSVRHN 60
61 LSLNKAFEKV PKRAGQQGKG MNWKISDEVR RDFLNKWNAG KLSKIRRGAS VTRQLQLHMS 120
121
|
| Detection Method: | |
| Confidence: | 229.529817 |
| Match: | 1d5vA_ |
| Description: | Adipocyte-transcription factor FREAC-11 (s12, fkh-14) |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [415-484] |
1 11 21 31 41 51
| | | | | |
1 KFGEIPAPES SSIDPRGIKA QKVKKSLQAT SSILGESAPQ LQRTQLTGQI STTTSMDVTT 60
61 NANVNNSSLS
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.498 | d.58.17 | Metal-binding domain |
| View | Download | 0.538 | d.52.1 | Alpha-lytic protease prodomain |
| View | Download | 0.446 | d.58.49 | YajQ-like |
| View | Download | 0.506 | d.58.43 | Mechanosensitive channel protein MscS (YggB), C-terminal domain |
| View | Download | 0.443 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.429 | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
| View | Download | 0.421 | d.15.7 | Immunoglobulin-binding domains |
| View | Download | 0.409 | a.22.1 | Histone-fold |
| View | Download | 0.401 | d.88.1 | SRF-like |
| View | Download | 0.391 | d.95.1 | Glucose permease domain IIB |
| View | Download | 0.383 | d.58.12 | eEF-1beta-like |
| View | Download | 0.365 | d.51.1 | Eukaryotic type KH-domain (KH-domain type I) |
| View | Download | 0.356 | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
| View | Download | 0.352 | b.24.1 | Hyaluronate lyase-like, C-terminal domain |
| View | Download | 0.343 | d.12.1 | Ribosomal proteins L23 and L15e |
| View | Download | 0.343 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.343 | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.339 | d.51.1 | Eukaryotic type KH-domain (KH-domain type I) |
| View | Download | 0.338 | g.3.7 | Scorpion toxin-like |
| View | Download | 0.337 | d.58.17 | Metal-binding domain |
| View | Download | 0.326 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.326 | g.10.1 | Hairpin loop containing domain-like |
| View | Download | 0.317 | b.43.4 | Riboflavin synthase domain-like |
| View | Download | 0.308 | d.57.1 | DNA damage-inducible protein DinI |
| View | Download | 0.307 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.304 | d.47.1 | Ribosomal protein L11, N-terminal domain |
| View | Download | 0.296 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.288 | d.74.5 | Hypothetical protein Yml108w |
| View | Download | 0.284 | d.71.1 | Cell division protein MinE topological specificity domain |
| View | Download | 0.283 | d.15.8 | Translation initiation factor IF3, N-terminal domain |
| View | Download | 0.280 | d.67.2 | Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain |
| View | Download | 0.263 | a.2.2 | Ribosomal protein L29 (L29p) |
| View | Download | 0.259 | d.58.5 | GlnB-like |
| View | Download | 0.248 | d.65.1 | Hedgehog/DD-pepidase |
| View | Download | 0.241 | d.16.1 | FAD-linked reductases, C-terminal domain |
| View | Download | 0.239 | b.48.1 | mu transposase, C-terminal domain |
| View | Download | 0.224 | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.220 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.220 | a.22.1 | Histone-fold |
| View | Download | 0.218 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.217 | d.74.3 | RBP11-like subunits of RNA polymerase |
| View | Download | 0.215 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.212 | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.210 | c.47.2 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
