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Protein Overview: SEC2

General Information:
Name(s) found: SEC2 / YNL272C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transportand for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    cytoplasmic membrane-bounded vesicle [IDALink to PubMed article]
    Biological Process: exocytosis [IMPLink to PubMed article]
    Molecular Function: guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDASEEAKRV SIQVTSLSTQ LIESVDKQSH LEEQLNKSLK TIASQKAAIE NYNQLKEDYN  60
   61 TLKRELSDRD DEVKRLREDI AKENELRTKA EEEADKLNKE VEDLTASLFD EANNMVADAR 120
  121 KEKYAIEILN KRLTEQLREK DTLLDTLTLQ LKNLKKVMHS LDNESTVTNN SNRYSTILSD 180
  181 SATSSSTSLN KVPTSYSLAS QDIYSGIVYS PSISSIRYDI SLYNEFLKFV AALPRCENIK 240
  241 ATSTESKLIR RLVNDEIQPI LKIDNASGIG WLVKKTLLSL IIDGLVVVEP LSGVNATYQI 300
  301 GYNSSSPAKQ ATSNMPKMFK FPLDSPPVAV HAACSFCGES RDDIIEHARM YILKTLHKTD 360
  361 DGKEQVTNTY PLCHWCLLKL RQTCEIFAFL RSLKVGAWHL EKLTTQNITK EDLEKFSEVT 420
  421 KHTKRDGRVS SQDKKTKRLS FMAGLGINSS TKNKPKMEIF SSETNAKPGQ PTTNIQRAWL 480
  481 QLCKLRCILH WTHIGIWAVD DSISSKIGPL VEDDSDEDQN DAISVRLQDK ALWKQDAKRP 540
  541 FSSSSAEESQ KSDAFDFESG DMENEITGES SSDESSSDGS STDNSTADSS SEDESSLADS 600
  601 TTSSADSSSP ESIDNGEGDD TVTKDDKSSI KSANNNEENS DCGDKKGRSI IKKKAPQRKI 660
  661 QKKKLLQDLD DLEEQFREES AIDQTEFENA ESNVKQNISS KRASSGDENS KKDNNEKTLK 720
  721 TNLTIGDKTQ EQIGENSPSS GLHASSSNDD NFDDAQEQQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) COP1 FCF2 FMP23 LCB5 PIP2 RET2 RET3 SCS2 SEC2 SEC21 SEC26 SEC27 SEC28
    View Details Gavin AC, et al. (2006) ERG1 SEC2
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 CDC28 CEG1 CKA1 CKA2 CKB1 CKB2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 FKH1 FYV8 GAS1 GCD2 GCD7 GCN3 GPH1 HHF1, HHF2 HRR25 HSP104 HTB1 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MBP1 MDH1 MDS3 MGE1 MGM101 MPH1 NET1 NOP1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 RRP1 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIN3 SIT4 SUI2 SUI3 TMA19 TSR1 UBP12 URE2 VMA4 YBR225W YER138C YGR017W YMR144W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..302] PSI-BLAST 14.522879 Heavy meromyosin subfragment
    2 View Details [303..456] deduced N/A No confident structure predictions are available.
    3 View Details [457..759] MSA 16.464996 View MSA. No confident structure predictions are available.
    4 View Details [567..759] MSA 1.33599 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

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