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Protein Overview: ERG1

General Information:
Name(s) found: ERG1 / YGR175C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed article]
    endoplasmic reticulum [TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: squalene monooxygenase activity [TAS]
    drug binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVNVAPEL INADNTITYD AIVIGAGVIG PCVATGLARK GKKVLIVERD WAMPDRIVGE  60
   61 LMQPGGVRAL RSLGMIQSIN NIEAYPVTGY TVFFNGEQVD IPYPYKADIP KVEKLKDLVK 120
  121 DGNDKVLEDS TIHIKDYEDD ERERGVAFVH GRFLNNLRNI TAQEPNVTRV QGNCIEILKD 180
  181 EKNEVVGAKV DIDGRGKVEF KAHLTFICDG IFSRFRKELH PDHVPTVGSS FVGMSLFNAK 240
  241 NPAPMHGHVI LGSDHMPILV YQISPEETRI LCAYNSPKVP ADIKSWMIKD VQPFIPKSLR 300
  301 PSFDEAVSQG KFRAMPNSYL PARQNDVTGM CVIGDALNMR HPLTGGGMTV GLHDVVLLIK 360
  361 KIGDLDFSDR EKVLDELLDY HFERKSYDSV INVLSVALYS LFAADSDNLK ALQKGCFKYF 420
  421 QRGGDCVNKP VEFLSGVLPK PLQLTRVFFA VAFYTIYLNM EERGFLGLPM ALLEGIMILI 480
  481 TAIRVFTPFL FGELIG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) ERG1 SEC2 TEF4
    View Details Ho Y, et al. (2002) DMA1 DMA2 ERG1 RPT2 RPT4 RVB1 SKP1 STI1 UBI4 YNL311C
    View Details Qiu et al. (2008) ERG1 ERG11 ERG25

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..56]
    [123..223]    		 PSI-BLAST 51.39794 Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
    2 View Details [57..122]
    [224..320]
    [339..350]
    [387..438]    		 PSI-BLAST 51.39794 Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
    3 View Details [321..338]
    [351..386]    		 PSI-BLAST 51.39794 Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
    4 View Details [439..496] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle