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View Structure Prediction Details

Protein: ERG1
Organism: Saccharomyces cerevisiae
Length: 496 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG1.

Description E-value Query
Range		 Subject
Range
gi|171471 - gi|171471|gb|AAA34592.1| squalene epoxidase [Saccharomyces cerevisiae]
 0.0 [1..496] [1..496]
ERG1_PANGI - Squalene monooxygenase OS=Panax ginseng PE=2 SV=1
 3.0E-91 [18..495] [74..520]
ERG14_ARATH - Squalene epoxidase 1 OS=Arabidopsis thaliana GN=SQE1 PE=1 SV=1
 1.0E-90 [1..495] [43..506]
gi|238878720 - gi|238878720|gb|EEQ42358.1| squalene monooxygenase [Candida albicans WO-1]
ERG1_CANAL - Squalene monooxygenase OS=Candida albicans GN=ERG1 PE=3 SV=1
ERG1_CANAL - Squalene monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG1 PE=3 SV=1
 1.0E-89 [15..495] [2..495]
ERG1_RAT - Squalene monooxygenase OS=Rattus norvegicus GN=Sqle PE=2 SV=1
 2.0E-89 [1..494] [103..568]
ERG1_MOUSE - Squalene monooxygenase OS=Mus musculus GN=Sqle PE=2 SV=1
 7.0E-89 [1..494] [102..567]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 8.0E-89 [3..495] [28..492]

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Predicted Domain #1
Region A:
Residues: [1-56] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVNVAPEL INADNTITYD AIVIGAGVIG PCVATGLARK GKKVLIVERD WAMPDR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [123-223] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDKVLEDSTI HIKDYEDDER ERGVAFVHGR FLNNLRNITA QEPNVTRVQG NCIEILKDEK  60
   61 NEVVGAKVDI DGRGKVEFKA HLTFICDGIF SRFRKELHPD H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fohA_
Description: Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [57-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVGELMQPGG VRALRSLGMI QSINNIEAYP VTGYTVFFNG EQVDIPYPYK ADIPKVEKLK  60
   61 DLVKDG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [224-320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPTVGSSFVG MSLFNAKNPA PMHGHVILGS DHMPILVYQI SPEETRILCA YNSPKVPADI  60
   61 KSWMIKDVQP FIPKSLRPSF DEAVSQGKFR AMPNSYL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [339-350] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRHPLTGGGM TV

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [387-438] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDSVINVLSV ALYSLFAADS DNLKALQKGC FKYFQRGGDC VNKPVEFLSG VL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fohA_
Description: Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [321-338] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PARQNDVTGM CVIGDALN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [351-386] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLHDVVLLIK KIGDLDFSDR EKVLDELLDY HFERKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fohA_
Description: Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [439-496] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKPLQLTRVF FAVAFYTIYL NMEERGFLGL PMALLEGIMI LITAIRVFTP FLFGELIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle