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View Structure Prediction Details

Protein: ERG1
Organism: Saccharomyces cerevisiae
Length: 496 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG1.

Description E-value Query
Range
Subject
Range
gi|171471 - gi|171471|gb|AAA34592.1| squalene epoxidase [Saccharomyces cerevisiae]
0.0 [1..496] [1..496]
ERG1_PANGI - Squalene monooxygenase OS=Panax ginseng PE=2 SV=1
3.0E-91 [18..495] [74..520]
ERG14_ARATH - Squalene epoxidase 1 OS=Arabidopsis thaliana GN=SQE1 PE=1 SV=1
1.0E-90 [1..495] [43..506]
gi|238878720 - gi|238878720|gb|EEQ42358.1| squalene monooxygenase [Candida albicans WO-1]
ERG1_CANAL - Squalene monooxygenase OS=Candida albicans GN=ERG1 PE=3 SV=1
ERG1_CANAL - Squalene monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG1 PE=3 SV=1
1.0E-89 [15..495] [2..495]
ERG1_RAT - Squalene monooxygenase OS=Rattus norvegicus GN=Sqle PE=2 SV=1
2.0E-89 [1..494] [103..568]
ERG1_MOUSE - Squalene monooxygenase OS=Mus musculus GN=Sqle PE=2 SV=1
7.0E-89 [1..494] [102..567]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
8.0E-89 [3..495] [28..492]

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Predicted Domain #1
Region A:
Residues: [1-56]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVNVAPEL INADNTITYD AIVIGAGVIG PCVATGLARK GKKVLIVERD WAMPDR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [123-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDKVLEDSTI HIKDYEDDER ERGVAFVHGR FLNNLRNITA QEPNVTRVQG NCIEILKDEK  60
   61 NEVVGAKVDI DGRGKVEFKA HLTFICDGIF SRFRKELHPD H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fohA_
Description: Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [57-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVGELMQPGG VRALRSLGMI QSINNIEAYP VTGYTVFFNG EQVDIPYPYK ADIPKVEKLK  60
   61 DLVKDG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [224-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPTVGSSFVG MSLFNAKNPA PMHGHVILGS DHMPILVYQI SPEETRILCA YNSPKVPADI  60
   61 KSWMIKDVQP FIPKSLRPSF DEAVSQGKFR AMPNSYL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [339-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRHPLTGGGM TV

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [387-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDSVINVLSV ALYSLFAADS DNLKALQKGC FKYFQRGGDC VNKPVEFLSG VL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fohA_
Description: Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [321-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PARQNDVTGM CVIGDALN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [351-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLHDVVLLIK KIGDLDFSDR EKVLDELLDY HFERKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1fohA_
Description: Phenol hydroxylase; Phenol hydroxylase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [439-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKPLQLTRVF FAVAFYTIYL NMEERGFLGL PMALLEGIMI LITAIRVFTP FLFGELIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.759 a.16.1 S15/NS1 RNA-binding domain
View Download 0.532 a.30.1 ROP protein
View Download 0.501 a.2.7 tRNA-binding arm
View Download 0.533 f.15.1 Small-conductance potassium channel
View Download 0.489 f.13.1 Family A G protein-coupled receptor-like
View Download 0.459 a.5.2 UBA-like
View Download 0.450 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.423 a.157.1 Skp1 dimerisation domain-like
View Download 0.416 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.408 a.55.1 IHF-like DNA-binding proteins
View Download 0.399 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.378 a.5.4 Elongation factor TFIIS domain 2
View Download 0.343 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.328 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.320 a.161.1 beta-catenin-interacting protein ICAT
View Download 0.307 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.301 a.112.1 Description not found.
View Download 0.300 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.296 a.4.1 Homeodomain-like
View Download 0.287 a.7.6 Ribosomal protein S20
View Download 0.286 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.281 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.280 a.51.1 Cytochrome c oxidase subunit h
View Download 0.277 a.126.1 Serum albumin-like
View Download 0.273 a.4.5 "Winged helix" DNA-binding domain
View Download 0.271 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.267 i.1.1 Ribosome and ribosomal fragments
View Download 0.267 d.58.1 4Fe-4S ferredoxins
View Download 0.260 a.24.17 Group V grass pollen allergen
View Download 0.250 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.245 a.4.1 Homeodomain-like
View Download 0.245 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.242 a.17.1 p8-MTCP1
View Download 0.241 a.65.1 Annexin
View Download 0.236 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.233 d.48.1 RecA protein, C-terminal domain
View Download 0.229 a.50.1 Anaphylotoxins (complement system)
View Download 0.221 a.2.7 tRNA-binding arm
View Download 0.216 a.64.2 Bacteriocin AS-48
View Download 0.215 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.214 a.101.1 Uteroglobin-like
View Download 0.213 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.212 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.211 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.204 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.200 a.4.6 C-terminal effector domain of the bipartite response regulators


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle