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Protein Overview: ERG25

General Information:
Name(s) found: ERG25 / YGR060W [SGD]
Description(s) found:
Found 30 descriptions.
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  • C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 309 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: ergosterol biosynthetic process [IDALink to PubMed article]
    Molecular Function: C-4 methylsterol oxidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVFNNATL SGLVQASTYS QTLQNVAHYQ PQLNFMEKYW AAWYSYMNND VLATGLMFFL  60
   61 LHEFMYFFRC LPWFIIDQIP YFRRWKLQPT KIPSAKEQLY CLKSVLLSHF LVEAIPIWTF 120
  121 HPMCEKLGIT VEVPFPSLKT MALEIGLFFV LEDTWHYWAH RLFHYGVFYK YIHKQHHRYA 180
  181 APFGLSAEYA HPAETLSLGF GTVGMPILYV MYTGKLHLFT LCVWITLRLF QAVDSHSGYD 240
  241 FPWSLNKIMP FWAGAEHHDL HHHYFIGNYA SSFRWWDYCL DTESGPEAKA SREERMKKRA 300
  301 ENNAQKKTN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERG1 ERG25

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PDS1 ERG25 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ERG25 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] Pfam 107.958607 Sterol desaturase No confident structure predictions are available.
    2 View Details [87..180] MSA 1.482995 View MSA. No confident structure predictions are available.
    3 View Details [181..309] FFAS03 1.01 No description for 2f5kA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.10787756282836 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56029029012385 bayes_pls_golite062009
  • chromatin binding
    		•  1.51511928418505 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.991756552156335 bayes_pls_golite062009
  • protein binding
    		•  0.759327550978008 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.57519986764207 bayes_pls_golite062009
  • DNA binding
    		•  0.293109488455755 bayes_pls_golite062009
  • catalytic activity
    		•  0.168308115787289 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle