Protein Overview: PDS1

General Information:
Name(s) found:	PDS1 / YDR113C [SGD]
Description(s) found: Found 35 descriptions. SHOW ALL	Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	373 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] spindle [IDA]
Biological Process:	protein import into nucleus [IMP] recombinational repair [IGI][IMP] mitotic sister chromatid segregation [IMP][IPI]
Molecular Function:	protein binding [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPANEDKEN NIVYTGNESS GINFPQTPAH LLKRSHSNIL KPPVRLDQLK RDANSNNGNT  60
   61 LKYIQGGKEV SPTKRLHTHA QQQGRLPLAA KDNNRSKSFI FPETSNQSKD ADLPQLQNTL 120
  121 SIRKNDQLRK LSQISRSRSR ANHNDLLSNS RKLQKYGSVL GYNALPKMKS LVLKDLADSG 180
  181 KNEESSDDDE GNEDSESKLG KKLQSALLKQ DSSDGENELN GGLGLFNEQG GLQQLIKNST 240
  241 KNEQKTKNDK SDKTDDYDIE IAPQRQEPLP YVPEGYSPFQ QDDIEKLKTF NSPYKLDLED 300
  301 EDDTPDKVDL LPLEQIDEEG EKDETECITR NQEEGAALPL LSKNFKEVAA VPTMELVYSE 360
  361 EGLDPEELED LVT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		ESP1 PDS1 SRC1
View Details	Krogan NJ, et al. (2006)		CBF5 JJJ1 PDS1 YPL009C
View Details	Ho Y, et al. (2002)		PDS1 SRP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PDS1	ERG25	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..373]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2