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Protein Overview: JJJ1

General Information:
Name(s) found: JJJ1 / YNL227C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 590 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: ribosomal large subunit biogenesis [IMPLink to PubMed article]
    regulation of cell size [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    Molecular Function: Hsp70/Hsc70 protein regulator activity [IDALink to PubMed article]
    ATPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTCYYELLG VETHASDLEL KKAYRKKALQ YHPDKNPDNV EEATQKFAVI RAAYEVLSDP  60
   61 QERAWYDSHK EQILNDTPPS TDDYYDYEVD ATVTGVTTDE LLLFFNSALY TKIDNSAAGI 120
  121 YQIAGKIFAK LAKDEILSGK RLGKFSEYQD DVFEQDINSI GYLKACDNFI NKTDKLLYPL 180
  181 FGYSPTDYEY LKHFYKTWSA FNTLKSFSWK DEYMYSKNYD RRTKREVNRR NEKARQQARN 240
  241 EYNKTVKRFV VFIKKLDKRM KEGAKIAEEQ RKLKEQQRKN ELNNRRKFGN DNNDEEKFHL 300
  301 QSWQTVKEEN WDELEKVYDN FGEFENSKND KEGEVLIYEC FICNKTFKSE KQLKNHINTK 360
  361 LHKKNMEEIR KEMEEENITL GLDNLSDLEK FDSADESVKE KEDIDLQALQ AELAEIERKL 420
  421 AESSSEDESE DDNLNIEMDI EVEDVSSDEN VHVNTKNKKK RKKKKKAKVD TETEESESFD 480
  481 DTKDKRSNEL DDLLASLGDK GLQTDDDEDW STKAKKKKGK QPKKNSKSTK STPSLSTLPS 540
  541 SMSPTSAIEV CTTCGESFDS RNKLFNHVKI AGHAAVKNVV KRKKVKTKRI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CBF5 JJJ1 PDS1 YPL009C
    View Details Ho Y, et al. (2002) ADE5,7 BCY1 CDC33 CPR6 GPH1 JJJ1 MRS6 PFK1 POR1 SEC27 TPK1 TPK3 VPS21 YHR033W YHR214W-A YPT52 YPT53 YPT7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data JJJ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] PSI-BLAST 119.512579 DnaJ chaperone, N-terminal (J) domain
    2 View Details [120..256] PSI-BLAST 9.69897 Cysteine-rich domain of the chaperone protein DnaJ.
    3 View Details [257..590] PSI-BLAST 10.0 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.00357390808173 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.87268634400658 bayes_pls_golite062009
  • protein binding
    		•  1.5095461875158 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.614892374098773 bayes_pls_golite062009
  • transporter activity
    		•  0.563782869756263 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.546706887747132 bayes_pls_golite062009
  • DNA binding
    		•  0.288048247241731 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle