YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: VPS21

General Information:
Name(s) found: VPS21 / YOR089C [SGD]
Description(s) found:
Found 34 descriptions.
SHOW ALL
  • Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 210 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    late endosome [IMPLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: endocytosis [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: GTPase activity [IMPLink to PubMed article][ISSLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTSVTSIKL VLLGEAAVGK SSIVLRFVSN DFAENKEPTI GAAFLTQRVT INEHTVKFEI  60
   61 WDTAGQERFA SLAPMYYRNA QAALVVYDVT KPQSFIKARH WVKELHEQAS KDIIIALVGN 120
  121 KIDMLQEGGE RKVAREEGEK LAEEKGLLFF ETSAKTGENV NDVFLGIGEK IPLKTAEEQN 180
  181 SASNERESNN QRVDLNAAND GTSANSACSC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDI1 MRS6 VPS21 YPT52
    View Details Krogan NJ, et al. (2006) GDI1 IDP3 MRS6 VPS21 YPT6
    View Details Ho Y, et al. (2002) BCY1 CAR2 CDC33 CYS4 GDI1 GND1 GTO1 JJJ1 LAA1 LYS1 MER1 MKT1 MRS6 POR1 RHO2 SAH1 SEC4 SNO2 SSN8 STE11 THI22 THO2 TIF1, TIF2 TPK1 TPK2 TPK3 TPS1 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPT1 YPT10 YPT31 YPT32 YPT52 YPT53 YPT6 YPT7
    View Details Qiu et al. (2008) VPS21 YPT52 YPT53

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS21 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] PSI-BLAST 948.0103 Ypt51

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTPase activity
    		•  4.52394549632777 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • microtubule motor activity
    		•  3.91769993918004 bayes_pls_golite062009
  • signal recognition particle binding
    		•  3.10924684520019 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.070470376968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • hydrolase activity
    		•  2.73675310079844 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.58603227794045 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.51786963027655 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • actin binding
    		•  2.2973522188675 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • structural molecule activity
    		•  2.08211451183607 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  2.04103162399905 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  1.95782378818812 bayes_pls_golite062009
  • tubulin binding
    		•  1.92557767696163 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.85943679361938 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.85937484083653 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.8521191028835 bayes_pls_golite062009
  • nucleotide binding
    		•  1.84603132945448 bayes_pls_golite062009
  • microtubule binding
    		•  1.84561785126784 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  1.81972511638668 bayes_pls_golite062009
  • kinase activity
    		•  1.80889641165674 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.63949223587737 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.60386625568858 bayes_pls_golite062009
  • ATP binding
    		•  1.5859264197035 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.55520429131224 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.53158018507951 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  1.52496551152043 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  1.52496551152043 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  1.52496551152043 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  1.52496551152043 bayes_pls_golite062009
    		• 1.5195709747438 bayes_pls_golite062009
  • antigen binding
    		•  1.43656260286121 bayes_pls_golite062009
  • actin filament binding
    		•  1.28204719195916 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.14475274823167 bayes_pls_golite062009
  • protein kinase activity
    		•  1.12864835254143 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  1.10251779925246 bayes_pls_golite062009
  • GDP-dissociation inhibitor binding
    		•  1.01467127484205 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • GMP binding
    		•  0.975301479415235 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.92105578610354 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • transcription activator activity
    		•  0.739301862805678 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.661834961742057 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.652333406433794 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.650964453464311 bayes_pls_golite062009
  • receptor activity
    		•  0.633514002718998 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.5886142102548 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.57614280790431 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.567883621045161 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.543512707823441 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.444874730945263 bayes_pls_golite062009
  • signal sequence binding
    		•  0.42240724331108 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  0.40217318916177 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.345873656782869 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.325013574811283 bayes_pls_golite062009
  • receptor binding
    		•  0.309955875731734 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.270268254152179 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • RNA binding
    		•  0.0693163519626152 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.0436504490626262 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.0436357112276422 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle