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View Structure Prediction Details

Protein: VPS21
Organism: Saccharomyces cerevisiae
Length: 210 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS21.

Description E-value Query
Range		 Subject
Range
RIC2_ORYSA - Ras-related protein RIC2 - Oryza sativa (Rice)
RIC2_ORYSJ - Ras-related protein RIC2 OS=Oryza sativa subsp. japonica GN=RIC2 PE=2 SV=2
gi|125555691 - gi|125555691|gb|EAZ01297.1| hypothetical protein OsI_23327 [Oryza sativa Indica Group]
 7.0E-91 [3..209] [10..216]
RB11A_PONAB - Ras-related protein Rab-11A OS=Pongo abelii GN=RAB11A PE=2 SV=3
CCDS10212.1_1 - null
ENSCJAT00000014411 - null
RB11A_RABIT - Ras-related protein Rab-11A OS=Oryctolagus cuniculus GN=RAB11A PE=2 SV=3
RB11A_RAT - Ras-related protein Rab-11A OS=Rattus norvegicus GN=Rab11a PE=1 SV=3
RB11A_PONPY - Ras-related protein Rab-11A - Pongo pygmaeus (Orangutan)
RB11A_MOUSE - Ras-related protein Rab-11A OS=Mus musculus GN=Rab11a PE=1 SV=3
RB11A_CANLF - Ras-related protein Rab-11A OS=Canis lupus familiaris GN=RAB11A PE=2 SV=3
ENSMMUG000000080... - null, null
gi|123999492, gi... - gi|61355514|gb|AAX41148.1| RAB11A member RAS oncogene family [synthetic construct], gi|61355506|gb|A...
gi|114657631 - gi|114657631|ref|XP_510490.2| PREDICTED: similar to rab11 [Pan troglodytes]
tr|G3I0B0|G3I0B0... - Ras-related protein Rab-11A OS=Cricetulus griseus GN=I79_016788 PE=3 SV=1
tr|M3WVD0|M3WVD0... - RAB11A, member RAS oncogene family OS=Felis catus GN=RAB11A PE=4 SV=1
gi|76675213|ref|... - PREDICTED: similar to RAB11a, member RAS oncogene family isoform 2 [Bos taurus], Isoform of Q2TA29, ...
RB11A_PIG - Ras-related protein Rab-11A OS=Sus scrofa GN=RAB11A PE=2 SV=3
gi|126277069 - gi|126277069|ref|XP_001367185.1| PREDICTED: similar to rab11 [Monodelphis domestica]
RAB11A - RAB11A, member RAS oncogene family
 2.0E-90 [3..208] [7..213]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-90 [2..208] [10..214]
ARA5_ARATH - Ras-related protein ARA-5 - Arabidopsis thaliana (Mouse-ear cress)
 2.0E-90 [3..209] [59..257]
gi|1370166 - gi|1370166|emb|CAA98160.1| RAB1C [Lotus japonicus]
 3.0E-90 [3..209] [4..200]
gi|4586580 - gi|4586580|dbj|BAA76422.1| rab-type small GTP-binding protein [Cicer arietinum]
 3.0E-90 [3..209] [4..200]

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Predicted Domain #1
Region A:
Residues: [1-210] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTSVTSIKL VLLGEAAVGK SSIVLRFVSN DFAENKEPTI GAAFLTQRVT INEHTVKFEI  60
   61 WDTAGQERFA SLAPMYYRNA QAALVVYDVT KPQSFIKARH WVKELHEQAS KDIIIALVGN 120
  121 KIDMLQEGGE RKVAREEGEK LAEEKGLLFF ETSAKTGENV NDVFLGIGEK IPLKTAEEQN 180
  181 SASNERESNN QRVDLNAAND GTSANSACSC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 948.0103
Match: 1ek0A_
Description: Ypt51
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
microtubule motor activity 3.91769993918004 bayes_pls_golite062009
signal recognition particle binding 3.10924684520019 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
structural constituent of ribosome 3.070470376968 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
hydrolase activity 2.73675310079844 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.58603227794045 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
microfilament motor activity 2.51786963027655 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
structural molecule activity 2.08211451183607 bayes_pls_golite062009
ribonucleoprotein binding 2.04103162399905 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 1.95782378818812 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 1.81972511638668 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
G-protein coupled receptor activity 1.63949223587737 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
apolipoprotein receptor activity 1.52496551152043 bayes_pls_golite062009
syntaxin-13 binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.52496551152043 bayes_pls_golite062009
1.5195709747438 bayes_pls_golite062009
antigen binding 1.43656260286121 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
nucleotide kinase activity 1.10251779925246 bayes_pls_golite062009
GDP-dissociation inhibitor binding 1.01467127484205 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
GMP binding 0.975301479415235 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
actin-dependent ATPase activity 0.92105578610354 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
transcription activator activity 0.739301862805678 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
transmembrane receptor activity 0.661834961742057 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.652333406433794 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
receptor activity 0.633514002718998 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
sterol transporter activity 0.57614280790431 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.567883621045161 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.444874730945263 bayes_pls_golite062009
signal sequence binding 0.42240724331108 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 0.40217318916177 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.325013574811283 bayes_pls_golite062009
receptor binding 0.309955875731734 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
DNA strand annealing activity 0.270268254152179 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
RNA binding 0.0693163519626152 bayes_pls_golite062009
G-protein-coupled receptor binding 0.0436504490626262 bayes_pls_golite062009
structural constituent of muscle 0.0436357112276422 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle