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null Combining with sulfonylurea to initiate a change in cell activity. Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity. null Combining with lactoferrin to initiate a change in cell activity. The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner. A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family. Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, to initiate a change in cell activity by a mechanism independent of coupling to G proteins. null Combining with transferrin to initiate a change in cell activity. Combining with acetylcholine to initiate a change in cell activity. Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triglyceride, cholesterol, or phospholipid, or a combination of these. The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane. Combining with an extracellular or intracellular messenger to initiate a change in cell activity. Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. Combining with a cytokinin to initiate a change in cell activity. A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated. Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity. Combining with any component or product of the complement cascade to initiate a change in cell activity. Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity. Combining with a member of the Wnt family of signaling molecules to initiate a change in cell activity. Combining with a cytokine to initiate a change in cell activity. Combining with an opsonin to initiate a change in cell activity. A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. Combining with ferritin, an iron-storing protein complex, to initiate a change in cell activity. Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity. Combining with glutamate to initiate a change in cell activity. Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. Combining with the hedgehog protein to initiate a change in cell activity. A receptor belonging to the FGFR family but lacking the tyrosine kinase domain. null Combining with an MHC class II protein complex to initiate a change in cellular activity. Combining with an extracellular messenger that results in a change in cellular activity involved in axon guidance. Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. Combining with an MHC class Ib protein complex to initiate a change in cellular activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. null Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: transmembrane receptor activity
Acc: GO:0004888
Aspect: Molecular Function
Desc: Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
Proteins in PDR annotated with:
   This term: 616 [Search]
   Term or descendants: 5553 [Refine Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004888 - transmembrane receptor activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle