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Protein Overview: GTO1

General Information:
Name(s) found: GTO1 / YGR154C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 356 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    Biological Process: glutathione metabolic process [ISSLink to PubMed article]
    Molecular Function: glutathione transferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSYKGTIS KTHSVFKPEK GRYYIYGALG CPFTHRAILA RSLKKLEPVL GLVLSHWQLD  60
   61 SKGARFLPAP HRPEKYKERF FTATGGIASA KLDESEELGD VNNDSARLFV DGAFDPVENI 120
  121 SRLSELYYLN DPKYPGTKFT VPVLWDSKTR KIVNNESGDI IRILNSGVFD EFIQSEETNV 180
  181 IDLVPHDLID EIDKNIKWVH PKINLGVYKV GLAENGKIYE TEVKTLFENL QKMECVLKEN 240
  241 YKRLEEQFSG NKQKILAKYF VLGQRLTEAD IRLYPSIIRF DVVYVQHFKC NLKTIRDGFP 300
  301 YLHLWLINLY WNYAEFRFTT DFNHIKLFYI RMEVSRNKIN QFGIVPLGPK PDISRL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) BCY1 CAR2 CYS4 GND1 GTO1 LAA1 LYS1 SAH1 SNO2 SSN8 THI22 THO2 TIF1, TIF2 TPK2 TPK3 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPT53

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] PSI-BLAST 42.09691 Class omega GST
    2 View Details [101..203] PSI-BLAST 42.09691 Class omega GST
    3 View Details [204..356] PSI-BLAST 3.221849 Chloride intracellular channel 1 (clic1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glutathione binding
    		•  2.07086805531749 bayes_pls_golite062009
  • glutathione transferase activity
    		•  1.85683051472829 bayes_pls_golite062009
  • antioxidant activity
    		•  1.78836688224506 bayes_pls_golite062009
  • peroxidase activity
    		•  1.62851025934188 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  1.62851025934188 bayes_pls_golite062009
  • binding
    		•  1.1101496519064 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  1.08052084417939 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.0279404567142 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  0.366096607480921 bayes_pls_golite062009
  • protein binding
    		•  0.341730456502484 bayes_pls_golite062009
  • selenium binding
    		•  0.237008126838281 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  0.163136748643487 bayes_pls_golite062009
    2
    Term Confidence Notes
  • glutathione transferase activity
    		•  3.95712498751783 bayes_pls_golite062009
  • glutathione binding
    		•  3.1027755387739 bayes_pls_golite062009
  • binding
    		•  1.73671487004343 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  1.08486797497934 bayes_pls_golite062009
  • transferase activity
    		•  1.05573069897577 bayes_pls_golite062009
  • catalytic activity
    		•  0.963623964325467 bayes_pls_golite062009
  • protein binding
    		•  0.816387415768278 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  0.0539815835450801 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle