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Protein Overview: SAH1

General Information:
Name(s) found: SAH1 / YER043C [SGD]
Description(s) found:
Found 31 descriptions.
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  • S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 449 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: methionine metabolic process [NASLink to PubMed article]
    selenocysteine metabolic process [NASLink to PubMed article]
    Molecular Function: adenosylhomocysteinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPAQNYKI ADISLAAFGR KEIELAEHEM PGLMAIRKAY GDVQPLKGAR IAGCLHMTIQ  60
   61 TAVLIETLVA LGAEVTWSSC NIYSTQDHAA AAIAASGVPV FAWKGETEEE YLWCIEQQLF 120
  121 AFKDNKKLNL ILDDGGDLTT LVHEKHPEML EDCFGLSEET TTGVHHLYRM VKEGKLKVPA 180
  181 INVNDSVTKS KFDNLYGCRE SLVDGIKRAT DVMLAGKVAV VAGYGDVGKG CAAALRGMGA 240
  241 RVLVTEIDPI NALQAAMEGY QVVTMEDASH IGQVFVTTTG CRDIINGEHF INMPEDAIVC 300
  301 NIGHFDIEID VAWLKANAKE CINIKPQVDR YLLSSGRHVI LLANGRLVNL GCATGHSSFV 360
  361 MSCSFSNQVL AQIALFKSND KSFREKHIEF QKTGPFEVGV HVLPKILDEA VAKFHLGNLG 420
  421 VRLTKLSKVQ SEYLGIPEEG PFKADHYRY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SAH1 YIR007W
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACH1 ACO1 ADH6 AFR1 AHP1 ARC1 ARF1 ARP4 ASA1 ATG17 ATG29 ATP3 BCY1 BUD13 CAR2 CCT6 CDC14 CDC33 CDC53 CIC1 CIS1 CKA1 CKA2 CKB1 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DED81 EGD1 EGD2 ERB1 ERG13 ERG6 FOL2 FPR1 FRS2 FUM1 GAS1 GFA1 GND1 GND2 GRH1 GRR1 GRX1 GTO1 GUS1 HAP2 HAP5 HAS1 HEF3 HHF1, HHF2 HTB2 HXT7 IGO1 ILV5 IMD2 IPP1 IST3 LAA1 LOC1 LRO1 LSP1 LYS1 MAM33 MET6 MRT4 MTQ1 MUB1 NAP1 NMD5 NOC2 NOC3 NOG1 NOP1 NOP16 NSA1 NSA2 NTF2 NUG1 OLA1 OYE2 PDC5 PDC6 PFK1 PGM2 PIL1 POL5 POR1 PRM2 PRO1 PRP43 PSE1 RAD1 RAD10 RHR2 RNR2 RSN1 SAH1 SAP190 SCP160 SCS2 SEC53 SEN15 SES1 SIR1 SIR3 SKP1 SNO2 SNU13 SOD1 SPB4 SPE3 SPT2 SRV2 SSK2 SSN8 SSQ1 SSZ1 STI1 TEF4 TFP1 THI22 THO2 THS1 TIF1, TIF2 TIF6 TMA19 TMA29 TPK2 TPK3 TSA2 UBA1 UBI4 UBR2 VMA4 VMA5 VPS21 WTM1 YBR028C YCK1 YCK2 YCK3 YDR306C YDR341C YGR111W YKL161C YNK1 YPT53 YRA1 YRA2 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SAH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193]
    [356..449]    		 PSI-BLAST 10163.0 S-adenosylhomocystein hydrolase
    2 View Details [194..355] PSI-BLAST 10163.0 S-adenosylhomocystein hydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenosylhomocysteinase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • trialkylsulfonium hydrolase activity
    		•  4.75102111339352 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • DNA binding
    		•  0.158019531459925 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0191997392158629 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.012678711735872 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle