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Protein Overview: ARC1

General Information:
Name(s) found: ARC1 / YGL105W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    methionyl glutamyl tRNA synthetase complex [IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: tRNA aminoacylation for protein translation [IMPLink to PubMed article]
    tRNA export from nucleus [IMPLink to PubMed article]
    Molecular Function: tRNA binding [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLVTKFES LIISKYPVSF TKEQSAQAAQ WESVLKSGQI QPHLDQLNLV LRDNTFIVST  60
   61 LYPTSTDVHV FEVALPLIKD LVASSKDVKS TYTTYRHILR WIDYMQNLLE VSSTDKLEIN 120
  121 HDLDLPHEVI EKKKKAPAGG AADAAAKADE DVSKKAKKQD HPRGKPDEET LKKLREEAKA 180
  181 KKAAKKAANA KQQQEQQNKA PEKPKPSAID FRVGFIQKAI KHPDADSLYV STIDVGDEEG 240
  241 PRTVCSGLVK HFPLDAMQER YVVVVCNLKP VNMRGIKSTA MVLCGSNDDK VEFVEPPKDS 300
  301 KAGDKVFFEG FGDEAPMKQL NPKKKIWEHL QPHFTTNDGL EVIFKDEEEK DHPVRKLTNA 360
  361 KGESFKVASI ANAQVR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARC1 GUS1 MES1
    View Details Krogan NJ, et al. (2006) ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
    View Details Gavin AC, et al. (2006) ARC1 GUS1 MES1
    View Details Ho Y, et al. (2002) AAC1 AAC3 AAT2 ACH1 ACO1 ADE5,7 ADH4 AFR1 AHA1 AHP1 ARC1 ARF1 ARO1 ARP2 ATG11 ATG12 ATG17 ATP3 CAR2 CDC10 CDC11 CDC12 CDC3 CDC33 CLU1 COF1 COR1 CPA2 CPR1 CPR6 CYR1 CYS4 EGD1 ENP1 ERG13 ERG6 FET4 FPR1 FRS2 FUM1 GCD11 GFA1 GND1 GND2 GRX1 GUS1 HEF3 HEM15 HHF1, HHF2 HRP1 HTA2 IPP1 KAP104 KTR3 LPD1 LRO1 LSP1 MET6 NAB2 NDE1 NTF2 OLA1 OYE2 PAA1 PFK1 PIL1 PPX1 PRB1 PRM2 PRO1 PTC7 RAD1 RAD10 REP1 REX2 RNR2 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 RPT4 RSN1 SAH1 SCP160 SEC18 SEC53 SEN15 SES1 SNU13 SOD1 TCB1 TEF4 TFP1 THS1 TIF1, TIF2 TMA19 TSA2 TYR1 UBA1 VMA4 VMA5 WTM1 YHR020W YHR033W YNK1 YNL035C YNL208W
    View Details Qiu et al. (2008) ARC1 FRS1 GUS1 MES1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ASF1 sample 3928 - Asf1-S-TEV-ZZ (in hir3delta mutant) Green EM, et al (2005)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] PSI-BLAST 18.221849 Class delta GST
    2 View Details [140..198] deduced N/A No confident structure predictions are available.
    3 View Details [199..376] PSI-BLAST 422.09691 EMAP II

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.24470496646396 bayes_pls_golite062009
  • catalytic activity
    		•  0.963623964325467 bayes_pls_golite062009
  • protein binding
    		•  0.608998866513518 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  0.44372379417457 bayes_pls_golite062009
  • transferase activity
    		•  0.352222179598631 bayes_pls_golite062009
  • transporter activity
    		•  0.343837470835258 bayes_pls_golite062009
  • glutathione transferase activity
    		•  0.20688408808374 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.184452716814807 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.17259853770512 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.141575430891772 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ligase activity, forming carbon-oxygen bonds
    		•  7.22739538544605 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.22739538544605 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.21678612388154 bayes_pls_golite062009
  • ligase activity
    		•  5.98606099120849 bayes_pls_golite062009
  • isoleucine-tRNA ligase activity
    		•  3.76808520367507 bayes_pls_golite062009
  • catalytic activity
    		•  1.41356903593784 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  1.15514226827836 bayes_pls_golite062009
  • binding
    		•  1.12496911405027 bayes_pls_golite062009
  • protein binding
    		•  0.341429946042706 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle