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Protein Overview: NHA1

General Information:
Name(s) found: NHA1 / YLR138W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 985 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cellular potassium ion homeostasis [IMPLink to PubMed article]
    response to osmotic stress [IMPLink to PubMed article]
    cellular monovalent inorganic cation homeostasis [IMPLink to PubMed article]
    Molecular Function: sodium:hydrogen antiporter activity [IDALink to PubMed article]
    cation:cation antiporter activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIWEQLEVS KAHVAYACVG VFSSIFSLVS LYVKEKLYIG ESTVAGIFGL IVGPVCLNWF  60
   61 NPLKWGNSDS ITLEITRIVL CLQIFAVAVE LPRKYMLKHW VSVTMLLLPV MTAGWLIIGL 120
  121 FVWILIPGLN FSASLLISAC ITATDPILAQ SVVSGKFAQR VPGHLRNLLS AESGCNDGMA 180
  181 FPFLFLSMNL ILHPGNGREI VKDWICVTIL YECLFGCLLG CFIGYVGRIT IRFAEKKNII 240
  241 DRESFLAFYV VLAFMCAGFG SILGVDDLLV SFAAGATFAW DGWFSQKTQE SNVSTVIDLL 300
  301 LNYAYFIYFG AIIPWSQFNN GEIGTNVWRL IILSIVVIFL RRIPAVMILR PLIPDIKSWR 360
  361 EALFVGHFGP IGVGAIFAAI LARGELESTF SDEPTPLNVV PSKEESKHWQ LIACIWPITC 420
  421 FFIVTSIIVH GSSVAIITLG RHLNTITLTK TFTTHTTNGD NGKSSWMQRL PSLDKAGRSF 480
  481 SLHRMDTQMT LSGDEGEAEE GGGRKGLAGG EDEEGLNNDQ IGSVATSGIP ARPAGGMPRR 540
  541 RKLSRKEKRL NRRQKLRNKG REIFSSRSKN EMYDDDELND LGRERLQKEK EARAATFALS 600
  601 TAVNTQRNEE IGMGGDEEED EYTPEKEYSD NYNNTPSFES SERSSSLRGR TYVPRNRYDG 660
  661 EETESEIESE DEMENESERS MASSEERRIR KMKEEEMKPG TAYLDGNRMI IENKQGEILN 720
  721 QVDIEDRNEA RDDEVSVDST AHSSLTTTMT NLSSSSGGRL KRILTPTSLG KIHSLVDKGK 780
  781 DKNKNSKYHA FKIDNLLIIE NEDGDVIKRY KINPHKSDDD KSKNRPRNDS VVSRALTAVG 840
  841 LKSKANSGVP PPVDEEKAIE GPSRKGPGML KKRTLTPAPP RGVQDSLDLE DEPSSEEDLG 900
  901 DSYNMDDSED YDDNAYESET EFERQRRLNA LGEMTAPADQ DDEELPPLPV EAQTGNDGPG 960
  961 TAEGKKKQKS AAVKSALSKT LGLNK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
    View Details Ho Y, et al. (2002) ETP1 MOH1 NHA1 YKR017C
    View Details Qiu et al. (2008) ENA1 NHA1 PMA2 TOK1 TRK1 TRK2 VMA9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NHA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..321] PSI-BLAST 4.69897 Cytochrome O ubiquinol oxidase, subunit I
    2 View Details [322..404] deduced N/A No confident structure predictions are available.
    3 View Details [405..985] MSA 94.448998 View MSA. No confident structure predictions are available.
    4 View Details [485..658] deduced N/A No confident structure predictions are available.
    5 View Details [659..985] PSI-BLAST 5.30103 No description for 2i1jA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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