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Protein Overview: TOK1

General Information:
Name(s) found: TOK1 / YJL093C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 691 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article][IMPLink to PubMed article]
    Biological Process: cellular potassium ion homeostasis [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: potassium channel activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRFMNSFAK QTLGYGNMAT VEQESSAQAV DSHSNNTPKQ AKGVLAEELK DALRFRDERV  60
   61 SIINAEPSST LFVFWFVVSC YFPVITACLG PVANTISIAC VVEKWRSLKN NSVVTNPRSN 120
  121 DTDVLMNQVK TVFDPPGIFA VNIISLVLGF TSNIILMLHF SKKLTYLKSQ LINITGWTIA 180
  181 GGMLLVDVIV CSLNDMPSIY SKTIGFWFAC ISSGLYLVCT IILTIHFIGY KLGKYPPTFN 240
  241 LLPNERSIMA YTVLLSLWLI WGAGMFSGLL HITYGNALYF CTVSLLTVGL GDILPKSVGA 300
  301 KIMVLIFSLS GVVLMGLIVF MTRSIIQKSS GPIFFFHRVE KGRSKSWKHY MDSSKNLSER 360
  361 EAFDLMKCIR QTASRKQHWF SLSVTIAIFM AFWLLGALVF KFAENWSYFN CIYFCFLCLL 420
  421 TIGYGDYAPR TGAGRAFFVI WALGAVPLMG AILSTVGDLL FDISTSLDIK IGESFNNKVK 480
  481 SIVFNGRQRA LSFMVNTGEI FEESDTADGD LEENTTSSQS SQISEFNDNN SEENDSGVTS 540
  541 PPASLQESFS SLSKASSPEG ILPLEYVSSA EYALQDSGTC NLRNLQELLK AVKKLHRICL 600
  601 ADKDYTLSFS DWSYIHKLHL RNITDIEEYT RGPEFWISPD TPLKFPLNEP HFAFMMLFKN 660
  661 IEELVGNLVE DEELYKVISK RKFLGEHRKT L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) NHA1 TOK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] MSA 6.107988 View MSA. No confident structure predictions are available.
    2 View Details [118..194] MSA 1.152993 View MSA. No confident structure predictions are available.
    3 View Details [195..350] ORFEUS 10.57 Potassium channel protein
    4 View Details [351..458] PSI-BLAST 57.512579 Potassium channel-related protein MthK
    5 View Details [459..638] PSI-BLAST 57.512579 Potassium channel-related protein MthK
    6 View Details [639..691] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • potassium channel activity
    		•  6.80950139957332 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  6.78740036921969 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  6.69340621375858 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.55904318827964 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.55320598344395 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  5.06264960439093 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.86252983188139 bayes_pls_golite062009
  • cation channel activity
    		•  4.85749153259346 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.77144021609018 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.3961579058414 bayes_pls_golite062009
  • gated channel activity
    		•  4.19619757426613 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  4.13359972196575 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.09858664479122 bayes_pls_golite062009
  • ion channel activity
    		•  3.86720832958006 bayes_pls_golite062009
  • channel activity
    		•  3.7587607940377 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  3.7587607940377 bayes_pls_golite062009
  • transporter activity
    		•  2.93091397928047 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.82224868778929 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.63886826791804 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.54207434157938 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  2.26062383880472 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  2.26062383880472 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.88952785751441 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.58358846593395 bayes_pls_golite062009
  • potassium ion transmembrane transporter activity
    		•  1.57069429249737 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.282641904073821 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.239024094835991 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.22529291758658 bayes_pls_golite062009
  • binding
    		•  0.144628283348863 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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