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Protein Overview: TRK1

General Information:
Name(s) found: TRK1 / YJL129C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1235 amino acids

    Gene Ontology:
    Cellular Component: membrane raft [IDALink to PubMed article]
    Biological Process: cellular potassium ion homeostasis [IDALink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: potassium ion transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHFRRTMSRV PTLASLEIRY KKSFGHKFRD FIALCGHYFA PVKKYIFPSF IAVHYFYTIS  60
   61 LTLITSILLY PIKNTRYIDT LFLAAGAVTQ GGLNTVDINN LSLYQQIVLY IVCCISTPIA 120
  121 VHSCLAFVRL YWFERYFDGI RDSSRRNFKM RRTKTILERE LTARTMTKNR TGTQRTSYPR 180
  181 KQAKTDDFQE KLFSGEMVNR DEQDSVHSDQ NSHDISRDSS NNNTNHNGSS GSLDDFVKED 240
  241 ETDDNGEYQE NNSYSTVGSS SNTVADESLN QKPKPSSLRF DEPHSKQRPA RVPSEKFAKR 300
  301 RGSRDISPAD MYRSIMMLQG KHEATAEDEG PPLVIGSPAD GTRYKSNVNK LKKATGINGN 360
  361 KIKIRDKGNE SNTDQNSVSS EANSTASVSD ESSLHTNFGN KVPSLRTNTH RSNSGPIAIT 420
  421 DNAETDKKHG PSIQFDITKP PRKISKRVST FDDLNPKSSV LYRKKASKKY LMKHFPKARR 480
  481 IRQQIKRRLS TGSIEKNSSN NVSDRKPITD MDDDDDDDDN DGDNNEEYFA DNESGDEDER 540
  541 VQQSEPHSDS ELKSHQQQQE KHQLQQNLHR MYKTKSFDDN RSRAVPMERS RTIDMAEAKD 600
  601 LNELARTPDF QKMVYQNWKA HHRKKPNFRK RGWNNKIFEH GPYASDSDRN YPDNSNTGNS 660
  661 ILHYAESILH HDGSHKNGSE EASSDSNENI YSTNGGSDHN GLNNYPTYND DEEGYYGLHF 720
  721 DTDYDLDPRH DLSKGSGKTY LSWQPTIGRN SNFLGLTRAQ KDELGGVEYR AIKLLCTILV 780
  781 VYYVGWHIVA FVMLVPWIIL KKHYSEVVRD DGVSPTWWGF WTAMSAFNDL GLTLTPNSMM 840
  841 SFNKAVYPLI VMIWFIIIGN TGFPILLRCI IWIMFKISPD LSQMRESLGF LLDHPRRCFT 900
  901 LLFPKAATWW LLLTLAGLNI TDWILFIILD FGSTVVKSLS KGYRVLVGLF QSVSTRTAGF 960
  961 SVVDLSQLHP SIQVSYMLMM YVSVLPLAIS IRRTNVYEEQ SLGLYGDMGG EPEDTDTEDD1020
 1021 GNDEDDDEEN ESHEGQSSQR SSSNNNNNNN RKKKKKKKTE NPNEISTKSF IGAHLRKQLS1080
 1081 FDLWFLFLGL FIICICEGDK IKDVQEPNFN IFAILFEIVS AYGTVGLSLG YPDTNQSFSR1140
 1141 QFTTLSKLVI IAMLIRGKNR GLPYSLDRAI ILPSDRLEHI DHLEGMKLKR QARTNTEDPM1200
 1201 TEHFKRSFTD VKHRWGALKR KTTHSRNPKR SSTTL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASC1 LIP5 TRK1
    View Details Qiu et al. (2008) NHA1 PMA1 TRK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] deduced N/A No confident structure predictions are available.
    2 View Details [138..625] MSA 15.408997 View MSA. No confident structure predictions are available.
    3 View Details [626..1235] Pfam 178.0 Cation transport protein No confident structure predictions are available.
    4 View Details [310..724] FFAS03 2.5 30S subunit
    5 View Details [725..893] deduced N/A No confident structure predictions are available.
    6 View Details [894..1031] deduced N/A No confident structure predictions are available.
    7 View Details [1032..1235] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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