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Protein Overview: ATG11

General Information:
Name(s) found: ATG11 / YPR049C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1178 amino acids

    Gene Ontology:
    Cellular Component: extrinsic to membrane [IDALink to PubMed article]
    Biological Process: peroxisome degradation [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADADEYSTA PTQQEITPLQ TTATIINAIS GECITTNVDF FVSLDKFKQF IARKWKIPPD  60
   61 QLLILLPYGN KLKPSMFKEL LINRSFTLND FYVYDRRLFS LVSKPTPTNL LTSKDSNPMN 120
  121 SPNSNDLTET LEYLIKNSHI SQYQGSDTIM IKPMPSPLED ADVDLSRLNY HSVTSLLTTN 180
  181 LGWLSALEID VHYFKSLIPD IIAHIKRIFD GLTVCSQYLK LYCFDVESLY NSNVQFLNQL 240
  241 VDNGMTSKWE KCFNDTLSKL TALEGDSLQK FINIESLLEN EKSVKILNHS INGKLNKIKR 300
  301 EIDENASFRD IITVNIDRLR QMFTPNESKF ELEDQMAESF EVLVSEMRTR SRNVLDKEEE 360
  361 EFNSQEFLKS MNVMLEKDKK ESVKTLFTIS QALYSQIGEL IDLKKSLQKH AVAILGNIAF 420
  421 TQMEILGIKR LLLNECNKDL ELYKKYEVEF AQVEDLPLIY GLYLIEKYRR LSWFQQILSF 480
  481 ISNFNQDLEL FKQNELRTRN KWVKNFGSIA TVFCEDLLSS SDFKRLNEYH SHTSPPNEDE 540
  541 EDENENSIAN YRQDLVKVSQ AIDNYMTQIK ETDVSEPIID LLSKTLFETK RFHIIYSNFK 600
  601 NNNNNSSNGN SISPEGSIAL KSDDVVKGYK TRIKKLESLL HEFQYSDIGH WPQGVLNTHL 660
  661 KPFRGSATSI NKKKFLGASV LLEPANISEV NIDSVSQANN HQIQELESNV DDLLHQLQLL 720
  721 KEENNRKSMQ ISEMGKKISD LEVEKTAYRE TLTNLNQELA RLTNEEQSHR TEIFTLNASF 780
  781 KKQLNDIISQ DNEKIEKLTG DYDDVSKSRE RLQMDLDESN KKHEQEVNLL KADIERLGKQ 840
  841 IVTSEKSYAE TNSSSMEKGE KFETIPLAED PGRENQISAY TQTLQDRIFD IISTNIFILE 900
  901 NIGLLLTFDN NNNIQIRRVK GLKKGTAQSN ILDESTQMLD AHDNSLIKSP VFQKLKDEYE 960
  961 LIKSVANGSE KDTQQSIFLG NITQLYDNKL YEVAVIRRFK DIETLAKKLT KENKIKRTLL1020
 1021 ERFQREKVTL RNFQIGDLAL FLPTRENVNS VGSMSSSTSS LSSSFSSVDL STPPPLDAMS1080
 1081 IQSSPSVIHS NVINQASISG RDKNKLMRPW AAFTAFEEST RYFLKDEKGL TKGKEWFVGR1140
 1141 IVTLEHFVAD SPSNNPFRLP KGSVWFQVTA VVVSYQGV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATG11 ATG17
    View Details Krogan NJ, et al. (2006) ATG11 ATG17 ATG29 CIS1 THI11 YBR197C
    View Details Gavin AC, et al. (2006) ATG11 ATG17 ATG29
    View Details Ho Y, et al. (2002) AAC1 AAC3 ADE5,7 AHA1 ARC1 ARO1 ARP2 ATG11 ATG12 ATG17 CAR2 CPA2 CPR6 FET4 GCD11 GFA1 GUS1 IPP1 PPX1 PRB1 PTC7 REP1 REX2 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 SEC18 TCB1 TIF1, TIF2 TYR1 YHR020W YHR033W YNL208W
    View Details Qiu et al. (2008) ATG11 ATG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PCF11 ATG11 2 Uetz P, et al. (2000)
    View Screen PCF11 ATG11 2 Unpublished Fields Lab Data
    View Screen PCF11 ATG11 2 Unpublished Fields Lab Data
    View Screen CAB3 ATG11 2 Hazbun TR, et al. (2003)
    View Screen CAB3 ATG11 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ATG11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 24.0 Heavy meromyosin subfragment
    2 View Details [377..482] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [483..553] PSI-BLAST 8.30103 Tropomyosin
    4 View Details [554..636] PSI-BLAST 8.30103 Tropomyosin
    5 View Details [637..698] PSI-BLAST 8.30103 Tropomyosin
    6 View Details [699..768] PSI-BLAST 8.30103 Tropomyosin
    7 View Details [769..925] PSI-BLAST 4.0 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    8 View Details [926..1178] MSA 27.829997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.24002842608348 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.29023721388505 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.23558162468883 bayes_pls_golite062009
  • DNA binding
    		•  1.22770101477594 bayes_pls_golite062009
  • protein binding
    		•  1.03780839342631 bayes_pls_golite062009
  • transcription factor activity
    		•  0.65548647141585 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.16394692014973 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle