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Protein Overview: PAA1

General Information:
Name(s) found: PAA1 / YDR071C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 191 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: chromatin organization [IMPLink to PubMed article]
    Molecular Function: diamine N-acetyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]
    aralkylamine N-acetyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSSSTLPL HMYIRPLIIE DLKQILNLES QGFPPNERAS EEIISFRLIN CPELCSGLFI  60
   61 REIEGKEVKK ETLIGHIMGT KIPHEYITIE SMGKLQVESS NHIGIHSVVI KPEYQKKNLA 120
  121 TLLLTDYIQK LSNQEIGNKI VLIAHEPLIP FYERVGFKII AENTNVAKDK NFAEQKWIDM 180
  181 ERELIKEEYD N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PAA1 PTC2 PTC3 PTC4
    View Details Krogan NJ, et al. (2006) PAA1 PTC2 PTC3 PTC4 VPS34
    View Details Gavin AC, et al. (2006) PAA1 PTC3
    View Details Gavin AC, et al. (2002) ENP1 HRR25 PAA1 PFK1 PTC3 PTC4 RAD50 TSR1 VPS15 YDR186C
    View Details Ho Y, et al. (2002) ADH4 ARC1 ASF1 COP1 ECM29 ENP1 GID8 GIN4 HEM15 HRP1 HTA2 IPP1 KAP104 KTR3 MDH1 MER1 NAB2 NDE1 NUM1 PAA1 PTC3 PTC4 RAD53 REP1 RPT4 SEF1 SKT5 SMC3 SPT16 SYF1 TCB1 TDA10 TPS1 UTP22 VHS1 YNL035C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UTP5 PAA1 2 Unpublished Fields Lab Data
    View Screen PTC2 PAA1 2 Uetz P, et al. (2000)
    View Screen NIT2 PAA1 2 Unpublished Fields Lab Data
    View Screen PTC4 PAA1 2 Unpublished Fields Lab Data
    View Screen CIT2 PAA1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PAA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] PSI-BLAST 107.9691 Serotonin N-acetyltranferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acyltransferase activity
    		•  3.21568934984495 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  3.08034095767905 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  3.04157204238388 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  3.04157204238388 bayes_pls_golite062009
  • acetyltransferase activity
    		•  2.84289106846615 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • transferase activity
    		•  1.72447231774431 bayes_pls_golite062009
  • diamine N-acetyltransferase activity
    		•  1.61977223570735 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.42711272311757 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  1.24328242407788 bayes_pls_golite062009
  • acyltransferase activity
    		•  1.2338745976101 bayes_pls_golite062009
    		• 0.717135555516362 bayes_pls_golite062009
  • transcription factor binding
    		•  0.61516943067272 bayes_pls_golite062009
  • ornithine decarboxylase regulator activity
    		•  0.455783614765891 bayes_pls_golite062009
  • binding
    		•  0.437605892967756 bayes_pls_golite062009
  • ornithine decarboxylase inhibitor activity
    		•  0.412837976409128 bayes_pls_golite062009
  • protein binding
    		•  0.283213965640071 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle