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Protein Overview: VPS15

General Information:
Name(s) found: VPS15 / YBR097W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1454 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Golgi membrane [TASLink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    inositol lipid-mediated signaling [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAQLSLVVQ ASPSIAIFSY IDVLEEVHYV SQLNSSRFLK TCKALDPNGE IVIKVFIKPK  60
   61 DQYSLRPFLQ RIRAQSFKLG QLPHVLNYSK LIETNRAGYM IRQHLKNNLY DRLSLRPYLQ 120
  121 DIELKFIAFQ LLNTLKDIHN LNIVHGDIKT ENILVTSWNW CILTDFAAFI KPVYLPEDNP 180
  181 GEFLFYFDTS KRRTCYLAPE RFNSKLYQDG KSNNGRLTKE MDIFSLGCVI AEIFAEGRPI 240
  241 FNLSQLFKYK SNSYDVNREF LMEEMNSTDL RNLVLDMIQL DPSKRLSCDE LLNKYRGIFF 300
  301 PDYFYTFIYD YFRNLVTMTT STPISDNTCT NSTLEDNVKL LDETTEKIYR DFSQICHCLD 360
  361 FPLIKDGGEI GSDPPILESY KIEIEISRFL NTNLYFPQNY HLVLQQFTKV SEKIKSVKEE 420
  421 CALLFISYLS HSIRSIVSTA TKLKNLELLA VFAQFVSDEN KIDRVVPYFV CCFEDSDQDV 480
  481 QALSLLTLIQ VLTSVRKLNQ LNENIFVDYL LPRLKRLLIS NRQNTNYLRI VFANCLSDLA 540
  541 IIINRFQEFT FAQHCNDNSM DNNTEIMESS TKYSAKLIQS VEDLTVSFLT DNDTYVKMAL 600
  601 LQNILPLCKF FGRERTNDII LSHLITYLND KDPALRVSLI QTISGISILL GTVTLEQYIL 660
  661 PLLIQTITDS EELVVISVLQ SLKSLFKTGL IRKKYYIDIS KTTSPLLLHP NNWIRQFTLM 720
  721 IIIEIINKLS KAEVYCILYP IIRPFFEFDV EFNFKSMISC CKQPVSRSVY NLLCSWSVRA 780
  781 SKSLFWKKII TNHVDSFGNN RIEFITKNYS SKNYGFNKRD TKSSSSLKGI KTSSTVYSHD 840
  841 NKEIPLTAED INWIDKFHII GLTEKDIWKI VALRGYVIRT ARVMAANPDF PYNNSNYRPL 900
  901 VQNSPPNLNL TNIMPRNIFF DVEFAEESTS EGQDSNLENQ QIYKYDESEK DSNKLNINGS 960
  961 KQLSTVMDIN GSLIFKNKSI ATTTSNLKNV FVQLEPTSYH MHSPNHGLKD NANVKPERKV1020
 1021 VVSNSYEGDV ESIEKFLSTF KILPPLRDYK EFGPIQEIVR SPNMGNLRGK LIATLMENEP1080
 1081 NSITSSAVSP GETPYLITGS DQGVIKIWNL KEIIVGEVYS SSLTYDCSST VTQITMIPNF1140
 1141 DAFAVSSKDG QIIVLKVNHY QQESEVKFLN CECIRKINLK NFGKNEYAVR MRAFVNEEKS1200
 1201 LLVALTNLSR VIIFDIRTLE RLQIIENSPR HGAVSSICID EECCVLILGT TRGIIDIWDI1260
 1261 RFNVLIRSWS FGDHAPITHV EVCQFYGKNS VIVVGGSSKT FLTIWNFVKG HCQYAFINSD1320
 1321 EQPSMEHFLP IEKGLEELNF CGIRSLNALS TISVSNDKIL LTDEATSSIV MFSLNELSSS1380
 1381 KAVISPSRFS DVFIPTQVTA NLTMLLRKMK RTSTHSVDDS LYHHDIINSI STCEVDETPL1440
 1441 LVACDNSGLI GIFQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AIM3 BAR1 COA4 GYL1 GYP5 HNT1 KIN2 MEF2 NCP1 PCL10 PRP28 RVS161 RVS167 SAE2 SLK19 TIM21 VPS15
    View Details Gavin AC, et al. (2006) VPS15 VPS30 VPS34 VPS38
    View Details Gavin AC, et al. (2002) ENP1 HRR25 PAA1 PFK1 PTC3 RAD50 TSR1 VPS15

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS15 Huh WK, et al. (2003)
    View Data VPS15 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71]
    [88..104]
    [323..390]    		 PSI-BLAST 174.228787 cAMP-dependent PK, catalytic subunit
    2 View Details [72..87]
    [105..322]    		 PSI-BLAST 174.228787 cAMP-dependent PK, catalytic subunit
    3 View Details [391..480] PSI-BLAST 83.39794 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    4 View Details [481..812] PSI-BLAST 83.39794 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    5 View Details [813..1053] deduced N/A No confident structure predictions are available.
    6 View Details [1054..1173] PSI-BLAST 4.30103 beta1-subunit of the signal-transducing G protein heterotrimer
    7 View Details [1174..1454] ORFEUS 14.46 Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • clathrin binding
    		•  3.06608550312523 bayes_pls_golite062009
  • binding
    		•  2.6374633159018 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.01243877392722 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.62227684952907 bayes_pls_golite062009
  • kinase activity
    		•  1.60994283310715 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.50380925936701 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.4515576307774 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • transferase activity
    		•  1.25186057612742 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.11259211979184 bayes_pls_golite062009
  • protein kinase activity
    		•  1.11004414957368 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.851483195437252 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.638990331710836 bayes_pls_golite062009
  • signal transducer activity
    		•  0.611492201912646 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.611492201912646 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.549076739943715 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  0.20777471813851 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.00492507437049428 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle