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View Structure Prediction Details

Protein: VPS15
Organism: Saccharomyces cerevisiae
Length: 1454 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS15.

Description E-value Query
Range		 Subject
Range
VPS15 - Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a m...
 0.0 [1..1454] [1..1454]
PPK19_SCHPO - Serine/threonine-protein kinase ppk19 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ppk1...
ppk19 - serine /threonine protein kinase Ppk19
 0.0 [1..956] [1..959]
VPS15_PICPA - Putative serine/threonine-protein kinase VPS15 OS=Komagataella pastoris GN=VPS15 PE=3 SV=3
 0.0 [1..921] [1..840]
gi|15233564, gi|... - gi|7269836|emb|CAB79696.1| putative protein [Arabidopsis thaliana], gi|15233564|ref|NP_194667.1| pro...
 0.0 [1..829] [1..878]
ird1-PA - The gene immune response deficient 1 is referred to in FlyBase by the symbol Dmel\ird1 (CG9746, FBgn...
 0.0 [1..775] [1..740]
CE06671 - serine\/threonine kinase status:Partially_confirmed UniProt:Q23669 protein_id:CAA94175.1
 0.0 [1..784] [1..741]
gi|17028437 - gi|17028437|gb|AAH17537.1| Pik3r4 protein [Mus musculus]
 0.0 [1..663] [1..620]

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Predicted Domain #1
Region A:
Residues: [1-71] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAQLSLVVQ ASPSIAIFSY IDVLEEVHYV SQLNSSRFLK TCKALDPNGE IVIKVFIKPK  60
   61 DQYSLRPFLQ R

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [88-104] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSKLIETNRA GYMIRQH

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [323-390] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PISDNTCTNS TLEDNVKLLD ETTEKIYRDF SQICHCLDFP LIKDGGEIGS DPPILESYKI  60
   61 EIEISRFL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 174.228787
Match: 1cdkA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [72-87] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRAQSFKLGQ LPHVLN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [105-322] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNNLYDRLS LRPYLQDIEL KFIAFQLLNT LKDIHNLNIV HGDIKTENIL VTSWNWCILT  60
   61 DFAAFIKPVY LPEDNPGEFL FYFDTSKRRT CYLAPERFNS KLYQDGKSNN GRLTKEMDIF 120
  121 SLGCVIAEIF AEGRPIFNLS QLFKYKSNSY DVNREFLMEE MNSTDLRNLV LDMIQLDPSK 180
  181 RLSCDELLNK YRGIFFPDYF YTFIYDYFRN LVTMTTST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 174.228787
Match: 1cdkA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
clathrin binding 3.06608550312523 bayes_pls_golite062009
binding 2.6374633159018 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.01243877392722 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.62227684952907 bayes_pls_golite062009
kinase activity 1.60994283310715 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.50380925936701 bayes_pls_golite062009
protein transmembrane transporter activity 1.4515576307774 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
transferase activity 1.25186057612742 bayes_pls_golite062009
nuclear localization sequence binding 1.11259211979184 bayes_pls_golite062009
protein kinase activity 1.11004414957368 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.851483195437252 bayes_pls_golite062009
protein serine/threonine kinase activity 0.638990331710836 bayes_pls_golite062009
signal transducer activity 0.611492201912646 bayes_pls_golite062009
molecular transducer activity 0.611492201912646 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
nucleic acid binding 0.549076739943715 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
nuclear export signal receptor activity 0.20777471813851 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
primary active transmembrane transporter activity 0.00492507437049428 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [391-480] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTNLYFPQNY HLVLQQFTKV SEKIKSVKEE CALLFISYLS HSIRSIVSTA TKLKNLELLA  60
   61 VFAQFVSDEN KIDRVVPYFV CCFEDSDQDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [481-812] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QALSLLTLIQ VLTSVRKLNQ LNENIFVDYL LPRLKRLLIS NRQNTNYLRI VFANCLSDLA  60
   61 IIINRFQEFT FAQHCNDNSM DNNTEIMESS TKYSAKLIQS VEDLTVSFLT DNDTYVKMAL 120
  121 LQNILPLCKF FGRERTNDII LSHLITYLND KDPALRVSLI QTISGISILL GTVTLEQYIL 180
  181 PLLIQTITDS EELVVISVLQ SLKSLFKTGL IRKKYYIDIS KTTSPLLLHP NNWIRQFTLM 240
  241 IIIEIINKLS KAEVYCILYP IIRPFFEFDV EFNFKSMISC CKQPVSRSVY NLLCSWSVRA 300
  301 SKSLFWKKII TNHVDSFGNN RIEFITKNYS SK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [813-1053] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYGFNKRDTK SSSSLKGIKT SSTVYSHDNK EIPLTAEDIN WIDKFHIIGL TEKDIWKIVA  60
   61 LRGYVIRTAR VMAANPDFPY NNSNYRPLVQ NSPPNLNLTN IMPRNIFFDV EFAEESTSEG 120
  121 QDSNLENQQI YKYDESEKDS NKLNINGSKQ LSTVMDINGS LIFKNKSIAT TTSNLKNVFV 180
  181 QLEPTSYHMH SPNHGLKDNA NVKPERKVVV SNSYEGDVES IEKFLSTFKI LPPLRDYKEF 240
  241 G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1054-1173] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIQEIVRSPN MGNLRGKLIA TLMENEPNSI TSSAVSPGET PYLITGSDQG VIKIWNLKEI  60
   61 IVGEVYSSSL TYDCSSTVTQ ITMIPNFDAF AVSSKDGQII VLKVNHYQQE SEVKFLNCEC 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1174-1454] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRKINLKNFG KNEYAVRMRA FVNEEKSLLV ALTNLSRVII FDIRTLERLQ IIENSPRHGA  60
   61 VSSICIDEEC CVLILGTTRG IIDIWDIRFN VLIRSWSFGD HAPITHVEVC QFYGKNSVIV 120
  121 VGGSSKTFLT IWNFVKGHCQ YAFINSDEQP SMEHFLPIEK GLEELNFCGI RSLNALSTIS 180
  181 VSNDKILLTD EATSSIVMFS LNELSSSKAV ISPSRFSDVF IPTQVTANLT MLLRKMKRTS 240
  241 THSVDDSLYH HDIINSISTC EVDETPLLVA CDNSGLIGIF Q

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.46
Match: 1k32A
Description: Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle