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Protein Overview: ird1-PA

General Information:
Name(s) found: ird1-PA / FBpp0081466 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene immune response deficient 1 is referred to in FlyBase by the symbol Dmel\ird1 (CG9746, FBgn0260935). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5066479..5071540. It has the cytological map location 85D1-85D2. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to amino acid starvation; positive regulation of antibacterial peptide biosynthetic process; macroautophagy; regulation of antimicrobial peptide production. 10 alleles are reported. The phenotype of these alleles is annotated with: melanotic mass. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1342 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: cellular response to amino acid starvation [IMP]
    positive regulation of antibacterial peptide biosynthetic process [IMP]
    protein amino acid phosphorylation [IEA]
    macroautophagy [IMP]
    regulation of antimicrobial peptide production [IMP]
    Molecular Function: ATP binding [IEA]
    protein serine/threonine kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNQLVGIAP SQIYAVEHYF SGQFGSEIAF SSNMGSTRFF KVAKAKTDEG QIVVKVFVKH  60
   61 DPTLPLEDHK ERLEGIKKTL SLANAVNCLP FQRVELIDKA AYIMREYVKH SLYDRVSTRP 120
  121 FLTVLEKKWI TFQILCALNQ CHKQKICHGD IKLENILITS WNWILLSDFA SFKPTYLPED 180
  181 NPADYTYFFD TSRRRTCYIA PERFVKTLAS DDDGGNGNMS VIHTDSIIRL APSYAGNTLL 240
  241 PAMDIFSAGC ALLELWTEGT APFELSQLLA YRRGERDLVE KHLAGIENER LRNLLASMID 300
  301 IHSMNRKSAE DYLDQERGQL FPEYFYSFLQ SYLQMFSSTP IMSPDDKIQC LHKDIGHCIK 360
  361 VLTQAQDLTP EEEEKEEKKD PTLCARLPPE HDGLILIITV VTSCIRGLKQ SNTKIAALEL 420
  421 LQKLSKYTTS ETILDRILPY ILHLAQKSPA KVQVQAIETL TACLGMVKDI PRSDANVFPE 480
  481 YILPSITDLA SETSAVIVRV AFARNIAALA KSAVYFLEET QRNAPNDMPT PRYEAELNAL 540
  541 HDIVRQAVLS LLTDSQPVVK QTLMESGICD LCAFFGKEKA NDVILSHIMT FLNDEDKNLR 600
  601 GAFYDNIAGV AGYVGWQASD ILVPLLQQGF TDREEFVIAK AIRAVTILIE LGHIKKPAVT 660
  661 EIVQETACYL CHPNLWVRHE ICGMIATTAR NLSAIDVQCK IMPAIGAFLK APLIQVEKPH 720
  721 ILLDCVHPPV PRQIFDSVLR FQDIHHFIRA LEARSRVRSQ TRQGALPQYE EMGQTLRNLF 780
  781 RRLSSEGLTD LIEMQLLAMN PFLISMKHKA LQDLDDTASG NGRIVVSRKQ VACHEYPLAD 840
  841 KASKMPLDNR SSEGPTLASP ASDAAITPLG AGGLAGSPAS GAVVLGVPTA TVSAATSLGE 900
  901 YTMPERNCWL ERSSECRKDL ESLTAKIKSR YNVLAISQRC SYDKLVTPYP PGWRMTGTLV 960
  961 AHLHEHSESV IKLASLRPHG SLFASGSIDG TVRLWDCSKL NGNQGVNKSR QVYSANTPIY1020
 1021 ALAACDSGQS LAVGGKDGSM LMMRIDRNSA KMTLQQALNQ NDHKDGPVVD MHAYDQATQS1080
 1081 VIVYATLYGG IVAWDTRMQH SAWRLQNELR HGVITTICAD PTGSWLATGT SGGKHICWDL1140
 1141 RFRLPIAEIK HPADSWIRKV ACHPTEPSYL ISASQSNNEV SVWNIETGQR QTVLWASPVA1200
 1201 ALSSASPSDP ATTCGILSGV VDGSPFILTG SSDQRIRYWD ITNPKNSSLK VPAANDNLAD1260
 1261 VAFNYGARLI DGSQVIEEQI ISMASTGDSQ QLRSSTEENP RSGPDMPTAS HHDAITDLLM1320
 1321 CKDKGQIYIA SASRNGVIKL WK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..378] PSI-BLAST 88.30103 MAP kinase p38
    2 View Details [379..715] PSI-BLAST 4.0 No description for 2h4mA was found.
    3 View Details [716..786] PSI-BLAST 81.69897 No description for 2ovpB was found.
    4 View Details [787..1139] PSI-BLAST 24.154902 Arp2/3 complex 41 kDa subunit ARPC1
    5 View Details [1140..1188] FFAS03 2.3 Actin interacting protein 1
    6 View Details [1189..1342] PSI-BLAST 80.0 No description for 2gnqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • binding
    		•  1.51590581981342 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • protein binding
    		•  1.36269611679417 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.684204466593894 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.196560862858137 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.5281054405163 bayes_pls_golite062009
  • kinase activity
    		•  1.5053563627859 bayes_pls_golite062009
  • protein binding
    		•  1.35583841097129 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.33036729957356 bayes_pls_golite062009
  • binding
    		•  1.19297522800508 bayes_pls_golite062009
  • protein kinase activity
    		•  1.03476232084853 bayes_pls_golite062009
  • transferase activity
    		•  0.913674310517261 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.618638900707402 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle