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Combining with hepatocye growth factor to initiate a change in cell activity. Combining with fibroblast growth factor to initiate a change in cell activity. Combining with insulin to initiate a change in cell activity. null Combining with the protein bride of sevenless (boss) to initiate a change in cell activity. Combining with an epidermal growth factor to initiate a change in cell activity. Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. Combining with an ephrin to initiate a change in cell activity. Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. Combining with an insulin-like growth factor to initiate a change in cell activity. Combining with brain-derived neurotrophic factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. Combining with macrophage colony stimulating factor to initiate a change in cell activity. Combining with vascular endothelial growth factor to initiate a change in cell activity. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity. Combining with platelet-derived growth factor to initiate a change in cell activity. Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: transmembrane receptor protein tyrosine kinase activity
Acc: GO:0004714
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity.
Synonyms:
  • neurotrophin TRKA receptor activity
  • neurite outgrowth regulating kinase activity
  • neurotrophin TRKB receptor activity
  • novel oncogene with kinase-domain activity
  • neurotrophin TRKC receptor activity
  • sevenless receptor activity
  • ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity
  • Drosophila Eph kinase activity
  • neurotrophin TRK receptor activity
  • insulin receptor protein-tyrosine kinase activity
  • anaplastic lymphoma kinase activity
  • ATP:protein-tyrosine O-phosphotransferase activity
  • ephrin-B3 receptor tyrosine kinase activity
  • receptor protein tyrosine kinase activity
  • receptor protein-tyrosine kinase activity
Proteins in PDR annotated with:
   This term: 182 [Search]
   Term or descendants: 272 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004714 - transmembrane receptor protein tyrosine kinase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle