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Protein Overview: VPS30

General Information:
Name(s) found: VPS30 / YPL120W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 557 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    Biological Process: autophagy [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCQTCHLPL QLDPSLEGLS LTQRNLLLSN NSIITATNEN VISNKGIEAA DNCGPQIPKE  60
   61 RLRRLGEIQN IKDLNLKDDK LITDSFVFLN HDDDDNANIT SNSREDQRYG NANGNDNKKA 120
  121 NSDTSDGTST FRDHDEEEQE ATDEDENQQI QLNSKTLSTQ VNAMTNVFNI LSSQTNIDFP 180
  181 ICQDCCNILI NRLKSEYDDA IKERDTYAQF LSKLESQNKE ISESNKEKQY SHNLSEKENL 240
  241 KKEEERLLDQ LLRLEMTDDD LDGELVRLQE KKVQLENEKL QKLSDQNLMD LNNIQFNKNL 300
  301 QSLKLQYELS LNQLDKLRKI NIFNATFKIS HSGPFATING LRLGSIPESV VPWKEINAAL 360
  361 GQLILLLATI NKNLKINLVD YELQPMGSFS KIKKRMVNSV EYNNSTTNAP GDWLILPVYY 420
  421 DENFNLGRIF RKETKFDKSL ETTLEIISEI TRQLSTIASS YSSQTLTTSQ DESSMNNAND 480
  481 VENSTSILEL PYIMNKDKIN GLSVKLHGSS PNLEWTTAMK FLLTNVKWLL AFSSNLLSKS 540
  541 ITLSPTVNYN DKTISGN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) VPS15 VPS30 VPS34 VPS38
    View Details Gavin AC, et al. (2002) ATG14 TFP1 VPS30

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen STE50 VPS30 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS30 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] PSI-BLAST 32.39794 Heavy meromyosin subfragment
    2 View Details [340..464] MSA 1.426974 View MSA. No confident structure predictions are available.
    3 View Details [465..557] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle