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Protein Overview: STE50

General Information:
Name(s) found: STE50 / YCL032W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 346 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: MAPKKK cascade involved in osmosensory signaling pathway [IMPLink to PubMed article][IPILink to PubMed article]
    response to pheromone [IDALink to PubMed article]
    signal transduction during filamentous growth [IMPLink to PubMed article][IPILink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: SAM domain binding [IDALink to PubMed article]
    protein kinase regulator activity [IDALink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDGKQAINE GSNDASPDLD VNGTILMNNE DFSQWSVDDV ITWCISTLEV EETDPLCQRL  60
   61 RENDIVGDLL PELCLQDCQD LCDGDLNKAI KFKILINKMR DSKLEWKDDK TQEDMITVLK 120
  121 NLYTTTSAKL QEFQSQYTRL RMDVLDVMKT SSSSSPINTH GVSTTVPSSN NTIIPSSDGV 180
  181 SLSQTDYFDT VHNRQSPSRR ESPVTVFRQP SLSHSKSLHK DSKNKVPQIS TNQSHPSAVS 240
  241 TANTPGPSPN EALKQLRASK EDSCERILKN AMKRHNLADQ DWRQYVLVIC YGDQERLLEL 300
  301 NEKPVIIFKN LKQQGLHPAI MLRRRGDFEE VAMMNGSDNV TPGGRL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MBA1 POL2 STE11 STE50
    View Details Krogan NJ, et al. (2006) STE11 STE50
    View Details Gavin AC, et al. (2006) STE11 STE50

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen STE50 ADY3 2 Unpublished Fields Lab Data
    View Screen STE50 FIP1 2 Unpublished Fields Lab Data
    View Screen STE50 PEP12 2 Unpublished Fields Lab Data
    View Screen STE50 SRB7 2 Unpublished Fields Lab Data
    View Screen STE50 YKL061W 2 Unpublished Fields Lab Data
    View Screen STE50 VPH1 2 Unpublished Fields Lab Data
    View Screen STE50 MUS81 2 Unpublished Fields Lab Data
    View Screen STE50 SYF1 2 Unpublished Fields Lab Data
    View Screen STE50 VPS51 2 Unpublished Fields Lab Data
    View Screen STE50 VPS30 2 Unpublished Fields Lab Data
    View Screen STE50 VMA8 2 Unpublished Fields Lab Data
    View Screen STE50 MAK3 2 Unpublished Fields Lab Data
    View Screen STE50 GLN3 2 Unpublished Fields Lab Data
    View Screen STE50 LDB18 2 Unpublished Fields Lab Data
    View Screen STE50 SAP1 2 Unpublished Fields Lab Data
    View Screen STE50 IFH1 2 Unpublished Fields Lab Data
    View Screen STE50 SMX3 2 Unpublished Fields Lab Data
    View Screen STE50 HPA2 2 Unpublished Fields Lab Data
    View Screen STE50 SPC72 2 Unpublished Fields Lab Data
    View Screen STE50 SEC15 2 Unpublished Fields Lab Data
    View Screen GIC2 STE50 2 Drees BL, et al. (2001)
    View Screen STE50 RRN9 2 Unpublished Fields Lab Data
    View Screen GIC1 STE50 2 Drees BL, et al. (2001)
    View Screen STE50 AHC2 2 Unpublished Fields Lab Data
    View Screen STE50 YNL086W 2 Unpublished Fields Lab Data
    View Screen STE50 YDL016C 2 Unpublished Fields Lab Data
    View Screen STE50 NTG2 2 Unpublished Fields Lab Data
    View Screen STE50 HRP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STE50 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] deduced N/A No confident structure predictions are available.
    2 View Details [197..346] Pfam 27.744727 Ras association (RalGDS/AF-6) domain No confident structure predictions are available.
    3 View Details [213..346] FFAS03 1.78 Solution Structure of Ras-binding Domain in Mouse AF-6 Protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.68693141392111 bayes_pls_golite062009
  • protein binding
    		•  2.12913758162323 bayes_pls_golite062009
  • SAM domain binding
    		•  2.00592266938182 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.48507851856487 bayes_pls_golite062009
  • DNA binding
    		•  0.100984195487788 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0714547564567439 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.0688320293797 bayes_pls_golite062009
  • protein binding
    		•  1.72968950672856 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.172760623576326 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.156922202244152 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0437862640556833 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle